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4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide

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4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide Suppliers list
Company Name: Biochempartner
Tel: 0086-13720134139
Email: candy@biochempartner.com
Products Intro: Product Name:SYN-115
CAS:870070-55-6
Purity:98% HPLC LCMS Package:10G;20G
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427
Email: sales@conier.com
Products Intro: Product Name:syn-115
CAS:870070-55-6
Purity:0.99 Package:1kg
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 +8613203830695
Email: laboratory@coreychem.com
Products Intro: Product Name:4-hydroxy-N-(4-methoxy-7-morpholinobenzo[d]thiazol-2-yl)-4-methylpiperidine-1-carboxamide
CAS:870070-55-6
Purity:98% Package:1g;1USD
Company Name: Baoji Guokang Bio-Technology Co., Ltd.
Tel: 0917-3909592 13892490616
Email: gksales1@gk-bio.com
Products Intro: Product Name:Tozadenant
CAS:870070-55-6
Purity:0.99 Package:5KG;1KG
Company Name: CR Corporation Lomited
Tel:
Email: fred.wen@crcorporation.cn
Products Intro: Product Name:4-hydroxy-N-(4-methoxy-7-morpholinobenzo[d]thiazol-2-yl)-4-methylpiperidine-1-carboxamide
CAS:870070-55-6

4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide manufacturers

  • Tozadenant
  • Tozadenant pictures
  • $15.00 / 1KG
  • 2021-07-13
  • CAS:870070-55-6
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
  • Tozadenant
  • Tozadenant pictures
  • $15.00 / 1KG
  • 2021-07-09
  • CAS:870070-55-6
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide Basic information
Product Name:4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide
Synonyms:4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide;SYN-115;4-Hydroxy-N-[4-methoxy-7-...;Tozadenant;4-hydroxy-N-(4-methoxy-7-morpholinobenzo[d]thiazol-2-yl)-4-methylpiperidine-1-carboxamide;Tozadenant (SYN-115);SYN-115 (Tozadenant);1-Piperidinecarboxamide, 4-hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-
CAS:870070-55-6
MF:C19H26N4O4S
MW:406.5
EINECS:
Product Categories:
Mol File:870070-55-6.mol
4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide Structure
4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide Chemical Properties
density 1.374
storage temp. Store at -20°C
solubility insoluble in EtOH; insoluble in H2O; ≥20.35 mg/mL in DMSO
form Powder
pka14.95±0.20(Predicted)
color White to off-white
Safety Information
MSDS Information
4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide Usage And Synthesis
DescriptionTozadenant is an adenosine A2A receptor antagonist (Kis = 11.5 and 6 nM for the human and rhesus monkey receptors, respectively). It increases the distance traveled and reduces contralateral asymmetry in the open field test in a rat model of Parkinson''s disease induced by 6-OHDA when administered at a dose of 30 mg/kg. Tozadenant (150 mg/kg) reverses locomotor deficits and restores novel object-stimulated locomotion in a marmoset model of MPTP-induced Parkinson''s disease.
DefinitionChEBI: Tozadenant is a member of benzothiazoles.
targetadenosine A2A receptor
referenceshauser ra, olanow cw, kieburtz kd et al. tozadenant (syn115) in patients with parkinson's disease who have motor fluctuations on levodopa: a phase 2b, double-blind, randomised trial. lancet neurol. 2014 aug;13(8):767-76.
4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide Preparation Products And Raw materials
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