Pep2m, myristoylated
中文名称 | Pep2m, myristoylated |
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中文同义词 | MYR-LYS-ARG-MET-LYS-VAL-ALA-LYS-ASN-ALA-GLN-OH;MYRQ-11 |
英文名称 | Pep2m, myristoylated |
英文同义词 | Pep2m, myristoylated |
CAS号 | 1423381-07-0 |
分子式 | C63H118N18O14S |
分子量 | 1383.81 |
EINECS号 | |
相关类别 | 目录多肽 |
Mol文件 | 1423381-07-0.mol |
结构式 | ![]() |
Pep2m, myristoylated 性质
密度 | 1.32±0.1 g/cm3(Predicted) |
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储存条件 | Store at -20°C |
酸度系数(pKa) | 3.25±0.10(Predicted) |
水溶解性 | Soluble to 1 mg/ml in sterile water |
NSF/GluR2 interactions
Pep2m, myristoylated (10 μM) blocks PKMζ-mediated AMPA receptor (AMPAR) potentiation.
Pep2m, myristoylated does not block the increase of PKMζ in the hippocampal slices during long-term potentiation (LTP) maintenance, indicating that blocking NSF/GluR2 interactions do not prevent the induction of PKMζ synthesis.
Pep2m, myristoylated blocks NSF/GluR2-mediated AMPAR trafficking, and reverses persistent potentiation at both the strongly stimulates synapses and the weakly stimulats synapses that underwent synaptic tagging and capture.
Pep2m, myristoylated (10 µg) results in an increase in paw withdrawal thresholds (PWTs) on nociceptive responses in the formalin test.
Animal Model: | Female and male Long-Evans hooded rats (8 weeks) |
Dosage: | 10 µg (in 20 µL) |
Administration: | Intrathecal injection |
Result: | Resulted in an increase in PWTs, in both male and female rats at various time points tested. |