Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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Tel: |
821-50328103-801 18930552037 |
Email: |
3bsc@sina.com |
Products Intro: |
Product Name:SANT-2;N-[3-(1H-BenziMidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzaMide CAS:329196-48-7 Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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Company Name: |
Shanghai Tauto Biotech Co., Ltd.
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Tel: |
021-51320588 |
Email: |
tauto@tautobiotech.com |
Products Intro: |
Product Name:SANT-2 CAS:329196-48-7 Purity:NLT 95% HPLC Package:10Mg;20Mg;50Mg;100Mg to graMs.Not More than tens of graMs. Remarks:AG-CR1-3514-M005
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| N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide Basic information |
Product Name: | N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide | Synonyms: | N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide;SANT-2;Hh Signaling Antagonist XIV, SANT-2;Benzamide, N-[3-(1H-benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxy-;Hh Signaling Antagonist XIV, SANT-2 - CAS 329196-48-7 - Calbiochem;N-(3-(1H-Benzo[d]imidazol-2-yl)-4-chlorophenyl)-3,4,5-triethoxybenzamide | CAS: | 329196-48-7 | MF: | C26H26ClN3O4 | MW: | 479.96 | EINECS: | | Product Categories: | | Mol File: | 329196-48-7.mol | ![N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide Structure](CAS/GIF/329196-48-7.gif) |
| N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide Chemical Properties |
Melting point | 210-211℃ | density | 1.287±0.06 g/cm3(Predicted) | storage temp. | -20°C | solubility | DMSO: soluble20mg/mL, clear | pka | 10.95±0.10(Predicted) | form | White powder | color | white to beige |
| N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide Usage And Synthesis |
Uses | SANT-2 is an inhibitor of Smo (Hedgehog signaling pathway) and SAG. | General Description | A nanomolar Smoothened (smo) antagonist that exhibits 2.3- and 6-fold weaker biological activity than SANT-1 (Cat. No. 559303), respectively, in antagonizing ShhNp- and SAG-stimulated hedgehog pathway activation in HEK 293-based (Shh-LIGHT2) reporter assays. Competitive binding studies show full replacement of Smo-bound cyclopamine (Cat. No. 239803) by SANT-1 and SANT-2 (Ki = 2.4 and 8.4 nM, respectively), while SANT-1 and SANT-2 are shown to compete against Smo-bound SAG-1.3 (Cat. Nos. 566660 & 566661) in an allosteric manner and that only SANT-2, but not SANT-1, is able to completely compete off bound SAG-1.3 (100% vs. 40% replacement by the respective compound at 10 μM). | Biochem/physiol Actions | SANT-2 is a potent sonic hedgehog pathway (shh) antagonist that directly inhibits by binding to the smoothened receptor. |
| N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide Preparation Products And Raw materials |
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