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N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide

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N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:SANT 2；SANT-2
CAS:329196-48-7
Package:10 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: LEAPCHEM CO., LTD.
Tel: +86-852-30606658
Email: market18@leapchem.com
Products Intro: Product Name:SANT-2
CAS:329196-48-7
Purity:0 Package:1g; 5g; 25g; 1kg; 5kg; 25kg Remarks:0
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:SANT-2
CAS:329196-48-7
Purity:>=95% Package:$23.9/1mg;$79.9/5mg;$266.9/25mg;$733.9/100mg;Bulk package Remarks:95%
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel: 821-50328103-801 18930552037
Email: 3bsc@sina.com
Products Intro: Product Name:SANT-2;N-[3-(1H-BenziMidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzaMide
CAS:329196-48-7
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
Company Name: Shanghai Tauto Biotech Co., Ltd.  
Tel: 021-51320588
Email: tauto@tautobiotech.com
Products Intro: Product Name:SANT-2
CAS:329196-48-7
Purity:NLT 95% HPLC Package:10Mg;20Mg;50Mg;100Mg to graMs.Not More than tens of graMs. Remarks:AG-CR1-3514-M005
N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide Basic information
Product Name:N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide
Synonyms:N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide;SANT-2;Hh Signaling Antagonist XIV, SANT-2;Benzamide, N-[3-(1H-benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxy-;Hh Signaling Antagonist XIV, SANT-2 - CAS 329196-48-7 - Calbiochem;N-(3-(1H-Benzo[d]imidazol-2-yl)-4-chlorophenyl)-3,4,5-triethoxybenzamide
CAS:329196-48-7
MF:C26H26ClN3O4
MW:479.96
EINECS:
Product Categories:
Mol File:329196-48-7.mol
N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide Structure
N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide Chemical Properties
Melting point 210-211℃
density 1.287±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: soluble20mg/mL, clear
pka10.95±0.10(Predicted)
form White powder
color white to beige
Safety Information
WGK Germany 3
MSDS Information
N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide Usage And Synthesis
UsesSANT-2 is an inhibitor of Smo (Hedgehog signaling pathway) and SAG.
General DescriptionA nanomolar Smoothened (smo) antagonist that exhibits 2.3- and 6-fold weaker biological activity than SANT-1 (Cat. No. 559303), respectively, in antagonizing ShhNp- and SAG-stimulated hedgehog pathway activation in HEK 293-based (Shh-LIGHT2) reporter assays. Competitive binding studies show full replacement of Smo-bound cyclopamine (Cat. No. 239803) by SANT-1 and SANT-2 (Ki = 2.4 and 8.4 nM, respectively), while SANT-1 and SANT-2 are shown to compete against Smo-bound SAG-1.3 (Cat. Nos. 566660 & 566661) in an allosteric manner and that only SANT-2, but not SANT-1, is able to completely compete off bound SAG-1.3 (100% vs. 40% replacement by the respective compound at 10 μM).
Biochem/physiol ActionsSANT-2 is a potent sonic hedgehog pathway (shh) antagonist that directly inhibits by binding to the smoothened receptor.
N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide Preparation Products And Raw materials
Tag:N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide(329196-48-7) Related Product Information
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