|
|
| | AVE8062A Basic information |
| Product Name: | AVE8062A | | Synonyms: | AVE8062A;AC 7700;Ombrabulin (hydrochloride);Ombrabulin (AVE8062) HCl;Ombrabulin (AVE8062) hydrochloride;Ombrabulin HCl;AC7700 (hydrochloride);AVE8062 (hydrochloride) | | CAS: | 253426-24-3 | | MF: | C21H27ClN2O6 | | MW: | 438.91 | | EINECS: | 682-340-5 | | Product Categories: | | | Mol File: | 253426-24-3.mol |  |
| | AVE8062A Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: soluble; Ethanol: soluble | | form | powder | | color | white to beige |
| | AVE8062A Usage And Synthesis |
| General Description | Ombrabulin is a member of the combretastatin A-4 compound class and is a tubulin-depolymerising tumour vascular-disrupting compound. | | Biochem/physiol Actions | Ombrabulin is a synthetic water-soluble combretastatin analog vascular disrupting agent. Ombrabulin is a tubulin polymerization inhibitor. Ombrabulin binds to the colchicine binding site of endothelial cell tubulin, inhibiting tubulin polymerization and inducing mitotic arrest and apoptosis in endothelial cells. |
| | AVE8062A Preparation Products And Raw materials |
|