| Company Name: |
J & K SCIENTIFIC LTD.
|
| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:HPI-1 Hydrate
CAS:1262770-72-8
Package:250Mg,25Mg
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| Company Name: |
Chemsky (shanghai) International Co.,Ltd
|
| Tel: |
021-50135380 |
| Email: |
shchemsky@sina.com |
| Products Intro: |
Product Name:HPI-1 Hydrate;1,4,5,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7-(2-Methoxyphenyl)-2-Methyl-5-oxo-3-quinolinecarboxylic Acid 2-Methoxyethyl Ester Hydrate
CAS:1262770-72-8
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing1@energy-chemical.com |
| Products Intro: |
Product Name:HPI-1 Hydrate
CAS:1262770-72-8
Purity:NULL Package:250mg;25mg Remarks:NULL
|
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| | HPI-1 Hydrate Basic information |
| | HPI-1 Hydrate Chemical Properties |
| | HPI-1 Hydrate Usage And Synthesis |
| Description | HPI-1 (hydrate) is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Sonic Hh (IC50 = 1.5 μM) without significantly affecting Wnt signaling (IC50 ≥ 30 μM). HPI-1 suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression, suggesting action at posttranslational modification of Gli protein or at the interaction of Gli with a co-factor. HPI-1 (hydrate) also inhibits signaling through the oncogenic Smoothened (Smo) mutant SmoM2 in neuron precursors, preventing cell proliferation. | | Uses | HPI-1 is a Hedgehog pathway inhibitor; Gli1/Gli2 inhibitor. |
| | HPI-1 Hydrate Preparation Products And Raw materials |
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