| Company Name: |
Toronto Research Chemicals
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| Tel: |
+1 (416) 665-9696 |
| Email: |
info@trc-canada.com |
| Products Intro: |
Package:150USD/2.5mg;1200USD/25mg
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| | Genistein-4,6,2',3',5',6'-d6 Basic information |
| Product Name: | Genistein-4,6,2',3',5',6'-d6 | | Synonyms: | Genistein-4,6,2',3',5',6'-d6 | | CAS: | | | MF: | C15H10O5 | | MW: | 270.2369 | | EINECS: | | | Product Categories: | Isotope Labelled Compounds;Tyrosine Kinase Inhibitors;Inhibitors | | Mol File: | Mol File |  |
| | Genistein-4,6,2',3',5',6'-d6 Chemical Properties |
| | Genistein-4,6,2',3',5',6'-d6 Usage And Synthesis |
| Chemical Properties | Light Yellow Solid | | Uses | Labelled Genistein (G350000). Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol |
| | Genistein-4,6,2',3',5',6'-d6 Preparation Products And Raw materials |
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