- NQDI 1
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- $1.00 / 1ASSAYS
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2019-09-06
- CAS:175026-96-7
- Min. Order: 1ASSAYS
- Purity: 95%~99%
- Supply Ability: per week:100kg
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| Product Name: | NQDI 1 | | Synonyms: | LESINURAD (RDEA-594) intermediate;2,7-Dihydro-2,7-dioxo-3H-naphtho[1,2,3-de]quinoline-1-carboxylic acid ethyl ester;NDQI 1;NQDI 1;3H-Naphtho[1,2,3-de]quinoline-1-carboxylic acid, 2,7-dihydro-2,7-dioxo-, ethyl ester;CS-1567;NQDI-1（97%）;NQDI-1;NQDI 1;NQDI1 | | CAS: | 175026-96-7 | | MF: | C19H13NO4 | | MW: | 319.31 | | EINECS: | | | Product Categories: | | | Mol File: | 175026-96-7.mol |  |
| | NQDI 1 Chemical Properties |
| Melting point | 310 °C (decomp) | | Boiling point | 581.4±50.0 °C(Predicted) | | density | 1.42±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: ≥5mg/mL (warmed to 60° C) | | form | powder | | pka | 10.76±0.40(Predicted) | | color | orange | | Stability: | Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| WGK Germany | 3 | | HS Code | 2933790090 |
| | NQDI 1 Usage And Synthesis |
| Description | Apoptosis signal-regulating kinase 1 (ASK1) is the ubiquitously expressed mitogen-activated protein kinase kinase kinase 5 involved in a wide range of biological functions that are dependent on cell survival or death. NQDI-1 is a specific inhibitor of ASK1 (IC50 = 3 μM; Ki = 500 nM) that demonstrates potent selectivity against various serine/threonine and tyrosine protein kinases. It has been used to promote survival of induced pluripotent stem cell populations and to protect neurons from reactive oxygen species-induced apoptosis in a model of ischemia. | | Uses | NQDI-1 is an ASK1 inhibitor which is of therapeutic potential against acute ischemic renal injury. ?Its protective effects are mediated through inhibition of apoptosis and oxidative stress. | | References | Volynets et al. (2011), Identification of 2H-naphtho[1,2,3-de]quinoline-2,7-diones as inhibitors of apoptosis signal-regulating kinase 1 (ASK1); Med. Chem., 54 2680
Nomura et al. (2013), An ASK1-p38 signaling pathway mediates hydrogen peroxide-induced toxicity in NG108-15 neuronal cells; Lett., 549 163
Chen et al. (2019), The MC4 receptor agonist RO27-3225 inhibits NLRP1-dependent neuronal pyroptosis via the ASK1/JNK/p38 MAPK pathway in a mouse model of intracerebral haemorrhage; J. Pharmacol., 176 1341
Ma et al. (2019), Low glucose and metformin-induced apoptosis of human ovarian cancer cells is connected to ASK1 via mitochondrial and endoplasmic reticulum stress associated pathways; Exp. Clin. Cancer Res., 38 77
Feng et al. (2018), Dual function of peroxiredoxin I in lipopolysaccharide-induced osteoblast apoptosis via reactive oxygen species and the apoptosis signal-regulating kinase 1 signaling pathway; Cell Death Discov., 4 47 |
| | NQDI 1 Preparation Products And Raw materials |
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