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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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| Products Intro: |
Product Name:(-)-AS 115
CAS:926657-43-4
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| | ()-AS 115 Basic information |
| Product Name: | ()-AS 115 | | Synonyms: | ()-AS 115;BTYYXSHZANWPEB-ZWKOTPCHSA-N;Carbamic acid, N-[2-[[(1R,2S)-2-(butoxymethyl)cyclohexyl]methoxy]ethyl]-, 2-fluorophenyl ester, rel- | | CAS: | 926657-43-4 | | MF: | C21H32FNO4 | | MW: | 381.48 | | EINECS: | | | Product Categories: | | | Mol File: | 926657-43-4.mol |  |
| | ()-AS 115 Chemical Properties |
| solubility | DMF: 12 mg/ml; DMSO: 12 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml |
| | ()-AS 115 Usage And Synthesis |
| Description | KIAA1363 is a 2-acetyl monoacylglyceryl ether (MAGE) hydrolase that is upregulated in aggressive cancers from various tissues.1 The enzyme catalyzes the hydrolysis of the 2-acetyl MAGE to MAGE and serves as a central enzyme in the PAF and LPA signaling network.2 AS 115 is a potent and selective inactivator of KIAA1363, displaying an IC50 value of 150 nM when tested as a racemic mixture in the invasive ovarian cancer cell line SKOV3.2 Treatment of SKOV3 cells with 10 μM AS-115 for 4 hours significantly reduced the formation of MAGE, alkyl-lysophosphatidylcholine, and alkyl-lysophosphatidic acid. The activity of the individual enantiomers of AS 115, i.e. (+)-AS 115 and (?)-AS 115, has not been determined. | | References | 1. Jessani, N., Liu, Y., Humphrey, M., et al. Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness Proc. Natl. Acad. Sci. USA 99(16),10335-10340(2002).
2. Chiang, K.P., Niessen, S., Saghatelian, A., et al. An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling Chem. Biol. 13(10),1041-1050(2006). |
| | ()-AS 115 Preparation Products And Raw materials |
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