| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:GPP 78
CAS:1202580-59-3
Purity:95% Package:1G;10G;100G Remarks:GPP 78 is a potent inhibitor of Nicotinamide phosphoribosyltransferase (Nampt) with an IC50 value of 3 nM.
|
| Company Name: |
Chengdu Peter-like Biotechnology Co., Ltd.
|
| Tel: |
028-81700200 18108052721 |
| Email: |
2850505130@qq.com |
| Products Intro: |
Product Name:GPP78
CAS:1202580-59-3
Purity:HPLC>=98% Package:5mg;10mg;20mg;50mg;100mg;200mg
|
|
| | CAY10618 Basic information |
| Product Name: | CAY10618 | | Synonyms: | CAY10618;1H-1,2,3-Triazole-1-octanaMide, N-[1,1'-biphenyl]-2-yl-4-(3-pyridinyl)-;GPP 78;CAY10618 Exclusive;N-(2-phenylphenyl)-8-(4-pyridin-3-yltriazol-1-yl)octanamide;GPP78,GPP-78 | | CAS: | 1202580-59-3 | | MF: | C27H29N5O | | MW: | 439.55 | | EINECS: | | | Product Categories: | | | Mol File: | 1202580-59-3.mol |  |
| | CAY10618 Chemical Properties |
| density | 1.15±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: 10 mg/ml | | pka | 14.80±0.70(Predicted) | | form | Liquid | | color | Colorless to light yellow |
| | CAY10618 Usage And Synthesis |
| Description | Nicotinamide phosphoribosyltransferase (Nampt) converts nicotinamide into nicotinamide mononucleotide (NMN), which is subsequently converted to NAD+ by NMN adenyltransferase. Cancer cells commonly have an unusually high rate of NAD+ turnover, suggesting that inhibition of Nampt might selectively target cancer cells. GPP 78 is a potent inhibitor of Nampt (IC50 = 3 nM). It induces cell death in the neuroblastoma cell line SH-SY5Y with an IC50 value of 3.8 nM through a process that appears to involve autophagy. | | Definition | ChEBI: N-(2-phenylphenyl)-8-[4-(3-pyridinyl)-1-triazolyl]octanamide is a member of biphenyls. |
| | CAY10618 Preparation Products And Raw materials |
|