| Company Name: |
MedBioPharmaceutical Technology Inc
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| Tel: |
021-69568360 18916172912 |
| Email: |
order@med-bio.cn |
| Products Intro: |
Product Name:GN25
CAS:1227401-27-5
Purity:98% Package:10mg; 25mg; 50mg Remarks:Medbio
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| Company Name: |
Shanghai Universal Biotech Co.,Ltd
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| Tel: |
18768175414 |
| Email: |
gaojun@univ-bio.com |
| Products Intro: |
Product Name:GN25
CAS:1227401-27-5
Package:10mg Remarks: 见优宁维官网
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| Product Name: | GN25 | | Synonyms: | GN25;DIIRLGMLDOPLPV-UHFFFAOYSA-N;Propanoic acid, 3-[(1,4-dihydro-5,8-dimethoxy-1,4-dioxo-2-naphthalenyl)thio]- | | CAS: | 1227401-27-5 | | MF: | C15H14O6S | | MW: | 322.33 | | EINECS: | | | Product Categories: | | | Mol File: | 1227401-27-5.mol |  |
| Boiling point | 608.4±55.0 °C(Predicted) | | density | 1.42±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | ≤0.25mg/ml in ethanol;5mg/ml in DMSO;10mg/ml in dimethyl formamide | | form | crystalline solid | | pka | 4.24±0.10(Predicted) |
| Description | The tumor suppressor gene, p53, is often mutated or suppressed in human cancers. Oncogenic K-Ras has been shown to inhibit p53 function by inducing Snail to bind and eliminate p53 through exocytosis. GN25 is a 2-thio-dimethoxy naphthoquinone analog that blocks Snail binding to p53 and induces p53 expression in cancer cells in a K-Ras dependent manner. At 10 μM, GN25 significantly reduces cell proliferation in K-Ras mutated A549 and HCT116 cell lines but not in wild type MKN-45 cells. In a xenograft mouse model, 10 mg/kg GN25 yields antitumoral effects by notably reducing tumor size and progression. | | references | [1]. lee sh, shen gn, jung ys, et al. antitumor effect of novel small chemical inhibitors of snail-p53 binding in k-ras-mutated cancer cells. oncogene. 2010 aug 12;29(32):4576-87. |
| | GN25 Preparation Products And Raw materials |
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