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| | γ-Secretase Inhibitor XXI Basic information |
| Product Name: | γ-Secretase Inhibitor XXI | | Synonyms: | N-[(1S)-2-[[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide;CoMpound E (secretase inhibitor);DuPont E;g-Secretase Inhibitor XXI;γ-Secretase Inhibitor BZ;γ-Secretase Inhibitor XXI;(S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S,Z)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanamide;(S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanamide | | CAS: | 209986-17-4 | | MF: | C27H24F2N4O3 | | MW: | 490.5 | | EINECS: | | | Product Categories: | | | Mol File: | 209986-17-4.mol |  |
| | γ-Secretase Inhibitor XXI Chemical Properties |
| Boiling point | 778.6±60.0 °C(Predicted) | | density | 1.31 | | storage temp. | = -70C | | solubility | Soluble in DMSO | | form | Liquid | | pka | 12.54±0.40(Predicted) | | color | White to off-white | | Sensitive | Light Sensitive |
| | γ-Secretase Inhibitor XXI Usage And Synthesis |
| Uses | A cell-permeable, potent, selective, peptidomimetic, non-transition-state analog inhibitor of -secretase and Notch processing | | Definition | ChEBI: Compound E is an L-alanine derivative that is the amide obtained by formal condensation of the carboxy group of N-[(3,5-difluorophenyl)acetyl]-L-alanine with the amino group of (3S)-3-amino-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one. An inhibitor of memapsin 2 (gamma-secretase). It has a role as an EC 3.4.23.46 (memapsin 2) inhibitor. It is a 1,4-benzodiazepinone, a L-alanine derivative and a difluorobenzene. | | storage | +4°C |
| | γ-Secretase Inhibitor XXI Preparation Products And Raw materials |
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