BD1063(盐酸盐)
中文名称 | BD1063(盐酸盐) |
---|---|
中文同义词 | BD1063(盐酸盐);1-(3,4-二氯苯乙基)-4-甲基哌嗪二盐酸盐;化合物BD1063;BD1063二盐酸盐;1-[2-(3,4-二氯苯基)乙基]-4-甲基哌嗪二盐酸盐 |
英文名称 | 1-[2-(3,4-Dichlorophenyl)ethyl]-4-Methylpiperazine Dihydrochloride |
英文同义词 | BD1063 (dhydrochloride);BD 1063 (hydrochloride);BD-1063 DHYDROCHLORIDE; BD 1063 DHYDROCHLORIDE;BD1063 HCl;1-(3,4-Dichlorophenethyl)-4-methylpiperazine dihydrochloride;Sigma Receptor,Inhibitor,inhibit,BD1063 dhydrochloride,BD-1063 dhydrochloride |
CAS号 | 206996-13-6 |
分子式 | C13H19Cl3N2 |
分子量 | 309.66 |
EINECS号 | |
相关类别 | 抑制剂;Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals |
Mol文件 | 206996-13-6.mol |
结构式 | ![]() |
BD1063(盐酸盐) 性质
储存条件 | room temp |
---|---|
溶解度 | H2O:>15mg/mL |
形态 | 粉末 |
颜色 | 白色至米色 |
水溶解性 | Soluble to 100 mM in water |
稳定性 | 自购买之日起 1 年内保持稳定。蒸馏水溶液可在 -20°C 下保存长达 3 个月。 |
Target | Value |
σ1R
(Cell-free assay) | 4.43 nM(Ki) |
BD1063 dose-dependently reduces ethanol self-administration in sP rats (3.3-11 mg/kg) and withdrawn, dependent Wistar rats (4-11 mg/kg) at doses that does not modify mean ethanol self-administration in non-dependent Wistar controls. BD1063 also reduces the breakpoints of sP rats to work for ethanol under a progressive-ratio reinforcement schedule. BD1063 dose-dependently reduces binge-like eating and the regularity of food responding, and blocks the increased eating rate in Palatable rats. In the light/dark conflict test, BD1063 antagonizes the increased time spent in the aversive compartment and the increased intake of the palatable diet, without affecting motor activity. The administration of BD1063 30 minutes before each paclitaxel dose prevents the development of cold and mechanical allodynia in WT mice. Moreover, the acute administration of BD1063 dose dependently reverses both types of paclitaxel-induced allodynia.
The novel σ-receptor ligands eurotransmitter antagonists.
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/04/30 | HY-18101A | BD1063(盐酸盐) BD1063 dhydrochloride | 206996-13-6 | 5mg | 770元 |
2024/04/30 | HY-18101A | BD1063(盐酸盐) BD1063 dhydrochloride | 206996-13-6 | 10mM * 1mLin Water | 847元 |