- AM095
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- $7.00 / 1KG
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2019-09-02
- CAS:1228690-36-5
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: JD 491
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| Product Name: | AM095 | | Synonyms: | AM 095 (parent compound);2-[4-[4-[3-methyl-4-[[(1r)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]phenyl]acetic Acid;AM-095 (free base);AM095 (free acid);[4'-[3-Methyl-4-[[[((R)-1-phenylethyl)oxy]carbonyl]amino]isoxazol-5-yl]biphenyl-4-yl]acetic acid;AM 095;AM-095;AM-095 FREE ACID;AM 095 FREE ACID;CS-1624;[1,1'-Biphenyl]-4-acetic acid, 4'-[3-methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl]- | | CAS: | 1228690-36-5 | | MF: | C27H24N2O5 | | MW: | 456.49 | | EINECS: | | | Product Categories: | | | Mol File: | 1228690-36-5.mol |  |
| | AM095 Chemical Properties |
| Boiling point | 641.9±55.0 °C(Predicted) | | density | 1.278±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | insoluble in EtOH; ≥42 mg/mL in DMSO; ≥8.12 mg/mL in H2O with ultrasonic | | form | Powder | | pka | 4.21±0.10(Predicted) | | color | White to off-white |
| | AM095 Usage And Synthesis |
| Biological Activity | am095 is a novel, potent and orally bioavailable antagonist of lysophosphatidic acid type 1 receptor (lpa1) with ic50 values of 0.73 and 0.98 μm for mouse or recombinant human lpa1, respectively [1]. | | in vitro | am095 has shown to inhibit lpa1-induced chemotaxis of both mouse lpa1/cho cells and human a2058 melanoma cells with ic50 values of 0.78 μm and 0.23μm [1]. | | in vivo | am095 could dose-dependently block lpa-induced histamine release with an ed50 value of 8.3 mg/kg in mice. additionally, am095 has been revealed to remarkably reduce the balf collagen and protein with an ed50 value of 10 mg/kg in lungs. am095 has also shown to decrease both macrophage and lymphocyte infiltration induced by bleomycin in mice [1]. | | target | LPA1 receptor | | references | [1] swaney js1, chapman c, correa ld, stebbins kj, broadhead ar, bain g, santini am, darlington j, king cd, baccei cs, lee c, parr ta, roppe jr, seiders tj, ziff j, prasit p, hutchinson jh, evans jf, lorrain ds. pharmacokinetic and pharmacodynamic characterization of an oral lysophosphatidic acid type 1 receptor-selective antagonist. j pharmacol exp ther. 2011 mar;336(3):693-700. |
| | AM095 Preparation Products And Raw materials |
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