| Company Name: |
SPIRO PHARMA
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| Tel: |
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| Email: |
eric_feng1954@126.com |
| Products Intro: |
Product Name:BI-99179
CAS:1291779-76-4
Purity:95% -98%HPLC Package:1GR;10GR;50GR;100GR;250GR;500GR;1KG;5KG;10KG;100KG
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| | BI-99179 Basic information |
| Product Name: | BI-99179 | | Synonyms: | BI-99179;(1R,3S)-N-[4-(1,3-benzoxazol-2-yl)phenyl]-N-methyl-3-(propanoylamino)cyclopentane-1-carboxamide;BI-99179
(BI99179);Cyclopentanecarboxamide, N-[4-(2-benzoxazolyl)phenyl]-N-methyl-3-[(1-oxopropyl)amino]-, (1R,3S)- | | CAS: | 1291779-76-4 | | MF: | C23H25N3O3 | | MW: | 391.46 | | EINECS: | | | Product Categories: | | | Mol File: | 1291779-76-4.mol |  |
| | BI-99179 Chemical Properties |
| Boiling point | 603.1±55.0 °C(Predicted) | | density | 1.25±0.1 g/cm3(Predicted) | | pka | 15.72±0.40(Predicted) | | form | Solid | | color | White to off-white |
| | BI-99179 Usage And Synthesis |
| Biochem/physiol Actions | BI 99179 is a non-cytotoxic (by LDH release; 30 μM, U937) orally available, brain-penetrant, highly potent and selective fatty acid synthase (FAS, FASN) inhibitor (IC50 = 79 nM by cell-free human FAS assay) with little or no inhibitory potency toward a panel of 30 receptors & channels (<20%>10 μM). BI 99179 inhibits cellular FAS activity in vitro (IC50 = 180 nM/human H1975, 600 nM/murine hypothalamic N-42 cells) and increases hypothalamic [malonyl-CoA] in rats in vivo (2 h post 10 mg/kg or 2-24 hr post 100 mg/kg p.o.). Note: adverse effects in rats are reported at day 4 (30 mg/kg) and day 9 (3 mg/kg). |
| | BI-99179 Preparation Products And Raw materials |
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