| Company Name: |
Hangzhou Sage Chemical Co., Ltd.
|
| Tel: |
+86057186818502 13588463833 |
| Email: |
info@sagechem.com |
| Products Intro: |
Product Name:2-PropenaMide, 3-(3,4-dihydroxyphenyl)-N-(2-phenylethyl)-
CAS:105955-01-9
Purity:98% Package:1g;5g;100g;Bulk
|
| Company Name: |
Shanghai Chaolan Chemical Technology Center
|
| Tel: |
QQ:65489617 15618227136 |
| Email: |
info@SuperLan-chem.com |
| Products Intro: |
Product Name:KS370G
CAS:105955-01-9
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing1@energy-chemical.com |
| Products Intro: |
Product Name:KS 370G >=98% (HPLC)
CAS:105955-01-9
Purity:NULL Package:25mg;5mg Remarks:NULL
|
|
| | 2-PropenaMide, 3-(3,4-dihydroxyphenyl)-N-(2-phenylethyl)- Basic information |
| | 2-PropenaMide, 3-(3,4-dihydroxyphenyl)-N-(2-phenylethyl)- Chemical Properties |
| Melting point | 154-155 °C(Solv: benzene (71-43-2); hexane (110-54-3); ethanol (64-17-5)) | | Boiling point | 575.5±50.0 °C(Predicted) | | density | 1.248±0.06 g/cm3(Predicted) | | pka | 9.42±0.10(Predicted) | | form | Solid | | color | White to off-white |
| | 2-PropenaMide, 3-(3,4-dihydroxyphenyl)-N-(2-phenylethyl)- Usage And Synthesis |
| Description | KS370G is an inhibitor of UUO-induced renal fibrosis markers expression. It acts by attenuating collagen deposition in the obstructed kidney and significantly lowering the expression of renal inflammatory chemokines/adhesion molecules and monocyte cells marker. | | in vitro | KS370G significantly inhibited the release of nitric oxide (NO) and the expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Treatment with KS370G also induced heme oxygenase (HO)-1 and suppressors of cytokine signaling (SOCS)-3 expression in the microglia._x000D_
_x000D_
Reference: Mol Neurobiol. 2013 Dec;48(3):863-74. https://pubmed.ncbi.nlm.nih.gov/23801310/ | | in vivo | The results show that KS370G significantly attenuated collagen deposition in the obstructed murine kidney and inhibited UUO-induced renal fibrosis markers expression, including fibronectin, type I collagen, vimentin, and α-smooth muscle actin (α-SMA). KS370G significantly lowered the expression of renal inflammatory chemokines/adhesion molecules and monocyte cells marker (MCP-1, VCAM-1, ICAM-1 and CD11b)._x000D_
_x000D_
Reference: Eur J Pharmacol. 2015 Mar 5;750:1-7. https://pubmed.ncbi.nlm.nih.gov/25620133/ | | target | KS370G is an inhibitor of UUO-induced renal fibrosis markers expression. |
| | 2-PropenaMide, 3-(3,4-dihydroxyphenyl)-N-(2-phenylethyl)- Preparation Products And Raw materials |
|