- KML-29
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- $0.01 / 1KG
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2020-01-13
- CAS:1380424-42-9
- Min. Order: 1KG
- Purity: 98%; 99%
- Supply Ability: 500g； 1kg; 25kg
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| Product Name: | KML-29 | | Synonyms: | KML-29;KML29;KML-29;KML 29;4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester;CS-2396;KML29 (KML-29);1-Piperidinecarboxylic acid, 4-[bis(1,3-benzodioxol-5-yl)hydroxymethyl]-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester;1,1,1,3,3,3-hexafluoropropan-2-yl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate;LPS,allodynia,Monoacylglycerol lipase,KML29,MAGL,inhibit,2-AG,Inhibitor,HFIP,KML 29,KML-29 | | CAS: | 1380424-42-9 | | MF: | C24H21F6NO7 | | MW: | 549.42 | | EINECS: | | | Product Categories: | Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals | | Mol File: | 1380424-42-9.mol |  |
| | KML-29 Chemical Properties |
| Melting point | 204-206°C | | Boiling point | 554.8±50.0 °C(Predicted) | | density | 1.511±0.06 g/cm3(Predicted) | | storage temp. | -20°C Freezer | | solubility | Chloroform (Slightly, Heated, Sonicated), Methanol (Slightly, Heated) | | pka | 13.32±0.29(Predicted) | | form | Solid | | color | White to Off-White |
| | KML-29 Usage And Synthesis |
| Description | Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. KML29 is an O-hexafluoroisopropyl carbamate analog of JZL 184 that potently and selectively inhibits MAGL (IC50s = 15, 43, and 5.9 nM in mouse, rat, and human brain proteomes, respectively) over FAAH (IC50s >50 μM). At 5-20 mg/kg, KML29 dose-dependently blocks mouse brain MAGL activity in vivo, without any measurable effect on FAAH activity. As a second generation MAGL inhibitor, KML29 supersedes the low-level cross reactivity that JZL 184 displays for FAAH yet still maintains comparable potency to its parent compound. | | Uses | KML-29 is an extremely specific monoacylglycerol lipase (MAGL) inhibitor. KML-2 should be useful to distinguish between actions of 2-arachidonoyl glycerol (an endogenous ligand of cannabinoid receptors that is deactivated by MAGL) and anandamide, another endocannabinoid. | | storage | Store at -20°C |
| | KML-29 Preparation Products And Raw materials |
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