7-丁基-6-(4-羟基苯基)-5H-吡咯并[2,3-B]吡嗪 基本信息
| 中文名称 | 7-丁基-6-(4-羟基苯基)-5H-吡咯并[2,3-B]吡嗪 |
|---|---|
| 中文同义词 | 7-丁基-6-(4-羟基苯基)-5H-吡咯并[2,3-B]吡嗪;4-(7-丁基-5H-吡咯并[2,3-B]吡嗪-6-基)苯酚;化合物 T21377;化合物 ALOISINE A;ALOISINE A,CDK抑制剂 |
| 英文名称 | RP107 |
| 英文同义词 | RP107;4-(7-BUTYL-5H-PYRROLO[2,3-B]PYRAZIN-6-YL)-PHENOL;ALOISINE A;ALOISINE A RP107;7-N-BUTYL-6-(4-HYDROXPHENYL)[5H]PYRROLO[2,3-B]PYRAZINE;7-N-BUTYL-6-(4-HYDROXYPHENYL)-[5H]PYRROLO[2,3-B]PYRAZINE;RP107, 7-n-Butyl-6-(4-hydroxyphenyl)-[5H]pyrrolo[2,3-b]pyrazine;RP107, 7-n-Butyl-6-(4-hydroxyphenyl)-[5H]pyrrolo[2,3-β]pyrazine |
| CAS号 | 496864-16-5 |
| 分子式 | C16H17N3O |
| 分子量 | 267.33 |
| EINECS号 | |
| 相关类别 | All Inhibitors;Inhibitors;Protein Kinase Inhibitors and Activators;Aromatics;Heterocycles |
| Mol文件 | 496864-16-5.mol |
| 结构式 | ![7-丁基-6-(4-羟基苯基)-5H-吡咯并[2,3-B]吡嗪 结构式](CAS/GIF/496864-16-5.gif) |
7-丁基-6-(4-羟基苯基)-5H-吡咯并[2,3-B]吡嗪 性质
| 熔点 | 281-283°C |
|---|---|
| 密度 | 1.227 |
| 储存条件 | Keep in dark place,Sealed in dry,2-8°C |
| 溶解度 | 可溶于DMSO（少许）、甲醇（少许） |
| 形态 | 黄色固体 |
| 酸度系数(pKa) | 9.67±0.15(Predicted) |
| 颜色 | 浅橙黄色 |
用途
A cell-permeable pyrrolo-pyrazine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks: IC50 =150nM, 120 nM, 400 nM and 200 nM for Cdk 1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p25, respectively). Also inhibits the activity of clycogen synthase kinase-3 (GSK-3,:(IC50 =500 nM and 1.5 uM for GSK-3a, GSK-3β, respectively), and c-Jun N-terminal kinase (JNK: IC50 approx. 3-10uM).