N-(1-acetyl-4-piperidinyl)-4-fluoro-BenzaMide
| 中文名称 | N-(1-acetyl-4-piperidinyl)-4-fluoro-BenzaMide |
|---|---|
| 中文同义词 | N-(1-乙酰基哌啶-4-基)-4-氟苯甲酰胺;化合物FK962 |
| 英文名称 | N-(1-acetyl-4-piperidinyl)-4-fluoro-BenzaMide |
| 英文同义词 | N-(1-acetyl-4-piperidinyl)-4-fluoro-BenzaMide;Benzamide, N-(1-acetyl-4-piperidinyl)-4-fluoro-;N-(1-acetylpiperidin-4-yl)-4-fluorobenzamide;FK962;Alzheimer,somatostatin,FK-962,FK 962,inhibit,FK962,Inhibitor,cognitive |
| CAS号 | 283167-06-6 |
| 分子式 | C14H17FN2O2 |
| 分子量 | 264.3 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 283167-06-6.mol |
| 结构式 |  |
N-(1-acetyl-4-piperidinyl)-4-fluoro-BenzaMide 性质
| 储存条件 | Sealed in dry,Room Temperature |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
FK962 是生长抑素 (somatostatin) 释放的增强剂，具有认知增强作用。
Somatostatin release
FK962 (1 nM-1 μM) significantly enhances high K + -evoked somatostatin release from rat hippocampal slices. FK962 also significantly reduces somatostatin-induced inhibition of Ca 2+ channels at 1-100 nM in single rat hippocampal neurons using whole-cell patch-clamp.
FK962 (0.1, 0.3 or 1.0 mg/kg; i.p.) and Donepezil (a single dose of 1 mg/kg) act synergistically to improve cognition in rats: as an add-on therapy for Alzheimer's disease.
| Animal Model: | Male Lister Hooded rats, weighing approximately 270-300 |
| Dosage: | 0.1, 0.3 or 1.0 mg/kg; Donepezil was given as a single dose of 1 mg/kg |
| Administration: | Administered i.p. |
| Result: | Resulted in minimal cognition enhancement when given separately. Combination showed a significantly greater effect on cognition. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-133025 | N-(1-acetyl-4-piperidinyl)-4-fluoro-BenzaMide FK962 | 283167-06-6 | 5mg | 1200元 |
| 2024/04/30 | S0535 | N-(1-acetyl-4-piperidinyl)-4-fluoro-BenzaMide FK962 | 283167-06-6 | 5mg | 2841.93元 |