GLPG 0492 manufacturers
- GLPG0492
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- $10.00 / 1kg
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2024-03-08
- CAS:1215085-92-9
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 1000kg
- GLPG-0492
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- $0.00 / 10gram
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2023-11-27
- CAS:1215085-92-9
- Min. Order: 10gram
- Purity: 99% min
- Supply Ability: 20 tons
- GLPG0492
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- $0.00 / 1kg
-
2023-09-05
- CAS:1215085-92-9
- Min. Order: 1kg
- Purity: 99.9%
- Supply Ability: 20tons
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| | GLPG 0492 Basic information |
| Product Name: | GLPG 0492 | | Synonyms: | GLPG 0492;GLPG-0492
(GLPG0492);Benzonitrile, 4-[(4S)-4-(hydroxymethyl)-3-methyl-2,5-dioxo-4-phenyl-1-imidazolidinyl]-2-(trifluoromethyl)-;4-[(4S)-4-(Hydroxymethyl)-3-methyl-2,5-dioxo-4-phenyl-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile | | CAS: | 1215085-92-9 | | MF: | C19H14F3N3O3 | | MW: | 389.33 | | EINECS: | | | Product Categories: | | | Mol File: | 1215085-92-9.mol |  |
| | GLPG 0492 Chemical Properties |
| Melting point | 66 - 71°C | | Boiling point | 544.0±60.0 °C(Predicted) | | density | 1.50±0.1 g/cm3(Predicted) | | storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere | | solubility | DMSO (Slightly), Ethanol (Slightly, Sonicated) | | pka | 13.50±0.10(Predicted) | | form | Solid | | color | White to Off-White | | Stability: | Hygroscopic |
| | GLPG 0492 Usage And Synthesis |
| Description | GLPG0492 is a selective androgen receptor modulator (SARM). It activates the androgen receptor in a transactivation assay (EC50 = 12 nM in HeLa cells expressing the human receptor). GLPG0492 (10 mg/kg per day) increases levator ani muscle weight, a marker of anabolic activity, but has no effect on ventral prostate weight, a marker of androgenic activity, in castrated rats. It increases twitch tension in isolated diaphragm strips, as well as increases the total distance run in a treadmill test and decreases gastrocnemius muscle fibrosis in the exercised-mdx mouse model of muscular dystrophy when administered at a dose of 30 mg/kg. GLPG0492 also reverses immobilization-induced muscle atrophy in a mouse model of hindlimb immobilization. | | Uses | GLPG-0492 is a non-steroidal Selective Androgen Receptor Modulator (SARM), which can be used to reduce muscle loss while sparing reproductive tissues. |
| | GLPG 0492 Preparation Products And Raw materials |
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