Mps1-IN-2 manufacturers
- Mps1-IN-2
-
- $1.00 / 1KG
-
2019-12-23
- CAS:1228817-38-6
- Min. Order: 1KG
- Purity: Min98% HPLC
- Supply Ability: g/kg/ton
|
| | Mps1-IN-2 Basic information |
| Product Name: | Mps1-IN-2 | | Synonyms: | Mps1-IN-2;9-Cyclopentyl-2-[[2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino]-5-methyl-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one;9-Cyclopentyl-2-[[2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino]-5-methyl-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one Mps1-in-2;CS-1837;Msp1-IN-2;Mps1 inhibitor 2;6H-Pyrimido[4,5-b][1,4]diazepin-6-one, 9-cyclopentyl-2-[[2-ethoxy-4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5,7,8,9-tetrahydro-5-methyl-;Mps1-IN-2 >=98% (HPLC) | | CAS: | 1228817-38-6 | | MF: | C26H36N6O3 | | MW: | 480.6 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 1228817-38-6.mol |  |
| | Mps1-IN-2 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | crystalline solid | | color | Light brown to brown |
| | Mps1-IN-2 Usage And Synthesis |
| Uses | Mps1-IN-2 is a novel Mps1 inhibitor. | | Definition | ChEBI: Mps1-IN-2 is a member of piperidines. | | Biological Activity | mps1-in-2 is a potent and selective atp-competitive inhibitor of mps1 kinase with the ic50 value of 145nm [1].mps1-in-2 has been reported to inhibit mps1 kinase activity with the ic50 value of 145nm, when screened at 1μm atp. in addition, mps1-in-2 has shown greater than 1000-fold selectivity to the alk and ltk enzyme. moreover, mps1-in-2 has been revealed to bound to the atp biding pocket of mpa1 and formed a hydrogen bond with the hinge backbone (glu603) at 2.74-å resolution. mps1-in-2 has been noted to abrogate sac function and override the checkpoint through direct inhibition of mps1[1]. | | references | [1] kwiatkowski n1, jelluma n, filippakopoulos p, soundararajan m, manak ms, kwon m, choi hg, sim t, deveraux ql, rottmann s, pellman d, shah jv, kops gj, knapp s, gray ns. small-molecule kinase inhibitors provide insight into mps1 cell cycle function. nat chem biol. 2010 may;6(5):359-68. doi: 10.1038/nchembio.345. epub 2010 apr 11. |
| | Mps1-IN-2 Preparation Products And Raw materials |
|