CYM 9484
| 中文名称 | CYM 9484 |
|---|---|
| 中文同义词 | 化合物 T10921;N-(4-(N,N-二甲基氨基磺酰基)苯基)-4-(羟基二苯基甲基)哌啶-1-硫代甲酰胺;CYM 9484,NPY Y2受体拮抗剂 |
| 英文名称 | N-[4-[(DiMethylaMino)sulfonyl]phenyl]-4-(hydroxydiphenylMethyl)-1-piperidinecarbothioaMide |
| 英文同义词 | N-[4-[(DiMethylaMino)sulfonyl]phenyl]-4-(hydroxydiphenylMethyl)-1-piperidinecarbothioaMide;CYM 9484;1-Piperidinecarbothioamide, N-[4-[(dimethylamino)sulfonyl]phenyl]-4-(hydroxydiphenylmethyl)-;N-(4-(N,N-Dimethylsulfamoyl)phenyl)-4-(hydroxydiphenylmethyl)piperidine-1-carbothioamide |
| CAS号 | 1383478-94-1 |
| 分子式 | C27H31N3O3S2 |
| 分子量 | 509.68 |
| EINECS号 | |
| 相关类别 | Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds |
| Mol文件 | 1383478-94-1.mol |
| 结构式 |  |
CYM 9484 性质
| 储存条件 | Store at RT |
|---|---|
| 溶解度 | 在 DMSO 中溶解度为 100 mM |
| 形态 | 粉末 |
| 颜色 | 白色至米白色 |
CYM 9484 是一种选择性强效神经肽 Y (NPY) Y2 受体拮抗剂，IC50 值为 19 nM。
|
NPYY 2 receptor 19 nM (IC 50 ) |
SF-11 is a selective, brain-penetrant NPY Y2 receptor antagonist with an IC 50 value of 190 nM. Systematically explore the SAR of the hit molecule SF-11 that leads to the identification of selective and highly potent small molecule NPY Y2 receptor antagonist CYM 9484 (Compound 16). CYM 9484 is 10-fold more potent than the hit molecule SF-11. CYM 9484 is prepared by the coupling of α,α-diphenylpiperidino-4-methanol with a variety of aryl isothiocyanates.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-107735 | CYM 9484 CYM 9484 | 1383478-94-1 | 5mg | 1500元 |
| 2024/04/30 | HY-107735 | CYM 9484 | 10 mM * 1 mLin DMSO | 1680元 |