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CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2)

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CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2) Suppliers list
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:IT1t dihydrochloride
CAS:1092776-63-0
Purity:98.00% Package:1 mL * 10mM (in DMSO)；10 mg；100 mg；200 mg；25 mg；5 mg；50 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
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Products Intro: Product Name:IT1t dihydrochloride
CAS:1092776-63-0
Purity:99% Package:10kg 25kg 200 kilograms per barrel Remarks:good
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
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Products Intro: Product Name:IT1t dihydrochloride
CAS:1092776-63-0
Purity:98% Package:10mg Remarks:V13399
Company Name: Nantong HI-FUTURE Biology Co., Ltd.
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Products Intro: Product Name:IT1tdihydrochloride
CAS:1092776-63-0
Purity:98% HPLC Package:100mg，500mg，1g，5g，10g
Company Name: Aladdin Scientific
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Products Intro: Product Name:IT1t dihydrochloride
CAS:1092776-63-0
Purity:>=99%(HPLC) Package:$99.9/5mg;$177.9/10mg;$355.9/25mg;$640.9/50mg;$1115.9/100mg;Bulk package Remarks:99%(HPLC)
CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2) Basic information
Product Name:CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2)
Synonyms:CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2);IT1t dihydrochloride;N,N'-Dicyclohexylcarbamimidothioic acid (5,6-dihydro-6,6-dimethylimidazo[2,1-b]thiazol-3-yl)methyl ester dihydrochloride;CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1;IT1t dihydrochloride,IT-1t dihydrochloride;IT1t (hydrochloride);CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2)
CAS:1092776-63-0
MF:C21H35ClN4S2
MW:443.11
EINECS:
Product Categories:
Mol File:1092776-63-0.mol
CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2) Structure
CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2) Chemical Properties
Melting point >187° (dec.)
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
color White
Safety Information
MSDS Information
CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2) Usage And Synthesis
DescriptionIT1t is a chemokine (C-X-C motif) receptor 4 (CXCR4) antagonist (IC50s = 8 and 11 nM for the human and rat receptors, respectively). It is selective for CXCR4 over human ether-a-go-go-related gene potassium channels (hERG/Kv11.1; IC50 = 13,240 nM). IT1t inhibits calcium mobilization induced by chemokine (C-X-C-motif) ligand 12 (CXCL12) in CEM cells (IC50 = 1.1 nM) and decreases CXCL12-induced migration of Jurkat cells (IC50 = 79.1 nM). It inhibits replication of the HIV-1 strain NL4-3 in MT-4 cells and isolated human peripheral blood mononuclear cells (PBMCs) stimulated with phytohemagglutinin (PHA; IC50s = 14.2 and 19 nM, respectively). IT1t (20 μM) reduces tumor growth in an MDA-MB-231-B zebrafish xenograft model.
UsesN,N''-Dicyclohexylcarbamimidothioic acid (5,6-dihydro-6,6-dimethylimidazo[2,1-b]thiazol-3-yl)methyl Ester Dihydrochloride is a potent CXCR4 antagonist. It also exhibits anti-viral activity against HIV.
storageStore at +4°C
references[1]. thoma g, streiff mb, kovarik j, et al. orally bioavailable isothioureas block function of the chemokine receptor cxcr4 in vitro and in vivo. j med chem, 2008, 51(24): 7915-7920.
CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2) Preparation Products And Raw materials
Tag:CarbaMiMidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-diMethyliMidazo[2,1-b]thiazol-3-yl)Methyl ester, hydrochloride (1:2)(1092776-63-0) Related Product Information