| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:BIM5078
CAS:337506-43-1
Purity:98% Package:1G;10G;100G Remarks:Hepatocyte nuclear factor (HNF)4α is a key regulator of gene expression in cell types playing an important role in metabolic homeostasis, such as hepatocytes, enterocytes, as well as pancreatic β cell
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:BIM5078
CAS:337506-43-1
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
MedBioPharmaceutical Technology Inc
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| Tel: |
021-69568360 18916172912 |
| Email: |
order@med-bio.cn |
| Products Intro: |
Product Name:1-[(2-Chloro-5-nitrophenyl)sulfonyl]-2-methyl-1H-benzimidazole
CAS:337506-43-1
Purity:98% Package:5mg; 25mg; 50mg; 10mg Remarks:Medbio
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing@energy-chemical.com |
| Products Intro: |
Product Name:BIM5078 >=98% (HPLC)
CAS:337506-43-1
Purity:NULL Package:25mg;5mg Remarks:NULL
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:BIM5078 Exclusive
CAS:337506-43-1
Purity:98% Package:5mg;10mg;25mg
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|
| | 1-[(2-Chloro-5-nitrophenyl)sulfonyl]-2-methyl-1H-benzimidazole Basic information |
| Product Name: | 1-[(2-Chloro-5-nitrophenyl)sulfonyl]-2-methyl-1H-benzimidazole | | Synonyms: | 1-(2′-Chloro-5′-nitrobenzenesulfonyl)-2-methylbenzimidazole;1-[(2-Chloro-5-nitrophenyl)sulfonyl]-2-methyl-1H-benzimidazole;BIM5078;BIM5078 Exclusive;1-(2-chloro-5-nitrophenyl)sulfonyl-2-methylbenzimidazole;1H-Benzimidazole, 1-[(2-chloro-5-nitrophenyl)sulfonyl]-2-methyl-;BIM5078 >=98% (HPLC) | | CAS: | 337506-43-1 | | MF: | C14H10ClN3O4S | | MW: | 351.76 | | EINECS: | | | Product Categories: | | | Mol File: | 337506-43-1.mol | ![1-[(2-Chloro-5-nitrophenyl)sulfonyl]-2-methyl-1H-benzimidazole Structure](CAS/20200119/GIF/337506-43-1.gif) |
| | 1-[(2-Chloro-5-nitrophenyl)sulfonyl]-2-methyl-1H-benzimidazole Chemical Properties |
| Boiling point | 573.1±60.0 °C(Predicted) | | density | 1.58±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: soluble10mg/mL, clear (warmed) | | pka | 0.49±0.10(Predicted) | | form | powder | | color | white to beige |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 45 | | RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | 3 |
| | 1-[(2-Chloro-5-nitrophenyl)sulfonyl]-2-methyl-1H-benzimidazole Usage And Synthesis |
| Description | HNF4α is a nuclear receptor transcription factor that controls the expression of many genes including those involved in glucose and lipid homeostasis and maintenance of epithelial differentiation. BIM5078 is an HNF4α antagonist that can repress the expression of known HNF4α target genes, inhibiting endogenous insulin expression in T6PNE cells with an IC50 value of 930 nM. BIM5078 binds directly to the ligand binding pocket of HNF4α with an EC50 value of 11.9 nM. However, BIM5078 has unfavorable pharmacokinetic properties including low plasma and microsomal stability (8% remaining after 3 hours and 32% after 1.25 hours, respectively), high binding to plasma proteins (98% bound after 4 hours), and low solubility (0.17 mg/ml after 18 hours). BI6015 is a structural analog of BIM5078 developed for more favorable pharmacokinetics. |
| | 1-[(2-Chloro-5-nitrophenyl)sulfonyl]-2-methyl-1H-benzimidazole Preparation Products And Raw materials |
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