2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE
| 中文名称 | 2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE |
|---|---|
| 中文同义词 | 化合物 T16865;SCH 28080,H +,K + -ATPASE抑制剂 |
| 英文名称 | 2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE |
| 英文同义词 | 3-(CYANOMETHYL)-2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-ALPHA]PYRIDINE;2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE;2-Methyl-8-(phenylmethoxy)imidazo-(1-2-A)pyrine-3-acetonitrile;Imidazo(1,2-A)pyridine-3-acetonitrile, 2-methyl-8-(phenylmethoxy)-;S28080;Schering compound 28080;SCH 28080;imidazo-(1-2-a)pyrine-3-acetonitrile |
| CAS号 | 76081-98-6 |
| 分子式 | C17H15N3O |
| 分子量 | 277.32 |
| EINECS号 | |
| 相关类别 | ATPase |
| Mol文件 | 76081-98-6.mol |
| 结构式 | ![2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE 结构式](CAS/GIF/76081-98-6.gif) |
2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE 性质
| 密度 | 1.16±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | -20°C |
| 溶解度 | DMSO：>10 mg/mL |
| 形态 | 固体 |
| 酸度系数(pKa) | 5.85±0.10(Predicted) |
| 颜色 | 白色至浅棕褐色 |
Ki: 0.12 μM ((H + /K + )-ATPase)
SCH28080 competitively inhibits the K
+
-stimulated hydrolysis of ATP, with a K
i
of 0.12 μM .
SCH28080 inhibits histamine-induced
[14C]
aminopyrine uptake into isolated rabbit parietal cells with an IC
50
of 0.029 μM.
SCH28080 causes a dose-dependent reduction in cell viability with IC
50
values of 22.9 µM and 15.3 µM after 2 h and 24 h treatments, respectively, and cell viability was below 10% at 100 µM already after 2 h treatment.
SCH28080 induces apoptosis and is cytotoxic at higher doses.
SCH28080 inhibits insulin secretion by activation of IK ATP and inhibition of L-type voltage-gated Ca
2+
channels, reduces cell viability and dose-dependently induces apoptosis/necrosis.
Cell Viability Assay
| Cell Line: | INS-1E cell |
| Concentration: | 3.1 μM, 6.25 μM, 12.5 μM, 25 μM, 50 μM, 100 μM |
| Incubation Time: | 2 hours, 24 hours |
| Result: | Caused a dose-dependent reduction in cell viability. |
SCH28080 (20 mg/kg; i.p.) inhibits gastric ulcers induced by pylorusligation in rats.
| Animal Model: | Male Wistar rat (280-350 g), the Shay rat model |
| Dosage: | 20 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Showed 91% inhibition on gastric ulcers induced by pylorusligation in rats. |
安全信息
| 安全说明 | 22-24/25 |
|---|---|
| WGK Germany | 3 |
| 提供商 | 语言 |
|---|---|
|
英文
|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-103261 | 2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE SCH28080 | 76081-98-6 | 1mg | 400元 |
| 2024/04/30 | HY-103261 | SCH28080 | 5 mg | 1100元 |