| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Email: |
ordercn@merckgroup.com |
| Products Intro: |
Product Name:Anti-SYVN1 antibody produced in rabbit
|
| Company Name: |
Riedel-de Haen AG
|
| Tel: |
800 558-9160 |
| Email: |
|
| Products Intro: |
Remarks:Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
|
|
| | Anti-Synovial apoptosis inhibitor 1 antibody produced in rabbit Basic information |
| | Anti-Synovial apoptosis inhibitor 1 antibody produced in rabbit Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous glycerol solution | | biological source | rabbit |
| | Anti-Synovial apoptosis inhibitor 1 antibody produced in rabbit Usage And Synthesis |
| Biological Activity | Synovial apoptosis inhibitor 1/ synoviolin (SYVN1) plays a key role in various processes, such as embryogenesis or negative regulation of tumor suppressor gene p53. The expression of SYVN1 is induced by IRE1 and ATF6, during ER stress, where it protects against ER-stress induced cell apoptosis. It is a part of endoplasmic reticulum associated degradation (ERAD) and degrades 3-hydroxy-3-methylglutaryl-coenzyme A, along with TCR-α and CD3-δ, which are ERAD substrates. It also sequesters p53, in the cytoplasm, and ubiquitinates it. Thus, it represses the various activities of p53, such as cell cycle regulation and apoptosis. SYVN1 is responsible for maintaining joint homeostasis and hence, is involved in the pathogenesis of arthropathy. In rheumatoid arthritis, it is overexpressed in synovial cells, leading to a μhyper-ERADμ state. It interacts with, and degrades tau and phosphorylated tau (p-tau). Therefore, it prevents tau-induced cytotoxicity and helps neuronal survival. |
| | Anti-Synovial apoptosis inhibitor 1 antibody produced in rabbit Preparation Products And Raw materials |
|