| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:WEE1-IN-4
CAS:622855-37-2
Package:1mg/RMB 4560
|
| Company Name: |
Henan Alpha Chemical Co., Ltd.
|
| Tel: |
0371-55013243 15324716602 |
| Email: |
2853979810@qq.com |
| Products Intro: |
Product Name:4-(2-chlorophenyl)-9-hydroxy-6H-pyrrolo[3,4-c]carbazole-1,3-dione
CAS:622855-37-2
Purity:98% Package:g；kg
|
|
| | Wee1 Inhibitor Basic information |
| Product Name: | Wee1 Inhibitor | | Synonyms: | Wee1 Inhibitor;Pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione, 4-(2-chlorophenyl)-9-hydroxy-;WEE1-IN-4;WEE-1-IN-4,WEE1 IN 4,WEE1IN4;4-(2-chlorophenyl)-9-hydroxy-6H-pyrrolo[3,4-c]carbazole-1,3-dione | | CAS: | 622855-37-2 | | MF: | C20H11ClN2O3 | | MW: | 362.77 | | EINECS: | | | Product Categories: | | | Mol File: | 622855-37-2.mol |  |
| | Wee1 Inhibitor Chemical Properties |
| storage temp. | -20°C | | solubility | DMSO: 10 mg/ml,Ethanol: 10 mg/ml | | form | A solid | | color | Yellow to orange |
| | Wee1 Inhibitor Usage And Synthesis |
| Biological Activity | Wee1 inhibitor is an inhibitor of the checkpoint kinase Wee1 (IC50 = 11 nM).1 It is selective for Wee1 over checkpoint kinase 1 (Chk1; IC50 = 440 nM). Wee1 inhibitor also inhibits the ATPase activity of LptB, an enzyme involved in the transport and assembly of LPS (IC50 = 25 μM for the E. coli enzyme).2 | | References | 1.Palmer, B.D., Thompson, A.M., Booth, R.J., et al.4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitutionJ. Med. Chem.49(16)4896-4911(2006)
2.Gronenberg, L.S., and Kahne, D.Development of an activity assay for discovery of inhibitors of lipopolysaccharide transportJ. Am. Chem. Soc.132(8)2518-2519(2010) |
| | Wee1 Inhibitor Preparation Products And Raw materials |
|