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Haoyuan Chemexpress Co., Ltd.
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Product Name:Exendin-4 (Acetate)
CAS:914454-01-6
Purity:>98% Package:900RMB/1mg
|
| Company Name: |
MedChemexpress LLC
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| Tel: |
021-58955995 |
| Email: |
sales@medchemexpress.cn |
| Products Intro: |
Product Name:Exendin-4 (Acetate)
CAS:914454-01-6
Purity:>98% Package:900RMB/1mg
|
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| | Exendin-4 (Acetate) Basic information |
| Product Name: | Exendin-4 (Acetate) | | Synonyms: | Exendin-4 (Acetate);Exenatide acetate
(Exendin-4 acetate);Exendin-4 Acetate,Exenatide acetate, >98%;Exenatide,Exendin 4 acetate,Glucagon Receptor,Exendin-4,inhibit,Exendin4 acetate,Exendin 4,Exendin4,GCGR,Inhibitor;Exendin-4 (48-86) amide (acetate) | | CAS: | 914454-01-6 | | MF: | C186H285N50O62RS | | MW: | 4245.62 | | EINECS: | | | Product Categories: | | | Mol File: | 914454-01-6.mol |  |
| | Exendin-4 (Acetate) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | PBS (pH 7.2): 3 mg/ml | | form | A crystalline solid | | color | White to off-white |
| | Exendin-4 (Acetate) Usage And Synthesis |
| Description | Exendin-4 (48-86) amide is a 39-amino acid peptide fragment corresponding to residues 48-86 of exendin-4, a peptide produced in the salivary gland of the Gila monster, and an agonist of the glucagon-like peptide 1 receptor (GLP-1R; IC50 = 3.5 nM).1,2 Radiolabeled exendin-4 (48-86) amide localizes to the pancreas, kidneys, and bladder in a porcine model of diabetes induced by streptozotocin .3 Exendin-4 (48-86) amide (10 nmol/kg) improves motor performance in the rotarod test in an mouse model of Parkinson’s disease induced by MPTP.4 It reduces MPTP-induced loss of dopaminergic neurons in the substantia nigra in the same model. Formulations containing exendin-4 (48-86) amide have been used in the treatment of type 2 diabetes mellitus. | | References | 1. Clardy, S.M., Mohan, J.F., Vinegoni, C., et al. Rapid, high efficiency isolation of pancreatic β-cells Sci. Rep. 5,13681(2015).
2. Doyle, M.E., Theodorakis, M.J., Holloway, H.W., et al. The importance of the nine-amino acid C-terminal sequence of exendin-4 for binding to the GLP-1 receptor and for biological activity Regul. Pept. 114(2-3),153-158(2003).
3. Nalin, L., Selvaraju, R.K., Velikyan, I., et al. Positron emission tomography imaging of the glucagon-like peptide-1 receptor in healthy and streptozotocin-induced diabetic pigs Eur. J. Nucl. Med. Mol. Imaging 41(9),1800-1810(2014).
4. Zhang, L., Zhang, L., Li, Y., et al. The novel dual GLP-1/GIP receptor agonist DA-CH5 is superior to single GLP-1 receptor agonists in the MPTP model of Parkinson’s disease J. Parkinsons Dis. 10(2),523-542(2020). |
| | Exendin-4 (Acetate) Preparation Products And Raw materials |
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