Company Name: |
Pharmacodia (Beijing) Co.,Ltd
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Tel: |
+86-400-851-9921 |
Email: |
sales@pharmacodia.com |
Products Intro: |
Product Name:FFN102 CAS:1234064-11-9 Package:10Mg-100g
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Company Name: |
Lynnchem
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Tel: |
86-(0)29-85992781 17792393971 |
Email: |
info@lynnchem.com |
Products Intro: |
Product Name:FFN102 CAS:1234064-11-9 Purity:95% Package:1mg;5mg
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Product Name: | FFN102 | Synonyms: | FFN102;FFN-102 (trifluoroacetate salt);FFN102 (Mini 102);FFN102 >=98% (HPLC) | CAS: | 1234064-11-9 | MF: | C13H11ClF3NO5 | MW: | 353.6783496 | EINECS: | | Product Categories: | | Mol File: | 1234064-11-9.mol | ![FFN102 Structure](CAS/20180713/GIF/1234064-11-9.gif) |
| FFN102 Chemical Properties |
storage temp. | Store at -20°C | solubility | DMF: 20 mg/ml; DMSO: 20 mg/ml | form | A crystalline solid |
| FFN102 Usage And Synthesis |
Description | FFN-102 is a fluorescent false neurotransmitter (FFN) that is a substrate for the dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT2). It is a pH-dependent fluorescent probe that labels dopamine cell bodies, axons, and presynaptic terminals. It can also be used to monitor dopamine exocytosis. It has a pKa of 6.2 and displays pH-dependent excitation spectra of 340 and 370 nm at pH 5 and 7.4, respectively, which correspond to vesicular and cytoplasmic pH values. The emission spectrum of FFN-102 is pH-independent at 453 nm, but the intensity of emission is pH-dependent with a higher intensity at a pH of 7.4. FFN-102 inhibits DAT (13.6% at a concentration of 10 μM) and the serotonin (5-HT) receptor subtype 5-HT2c (Ki = ~3 μM) but does not bind to 37 other central nervous system receptors and transporters, including dopamine receptors, up to a concentration of 10 μM. |
| FFN102 Preparation Products And Raw materials |
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