ABT-100
中文名称 | ABT-100 |
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中文同义词 | 化合物 T10223 |
英文名称 | ABT-100 |
英文同义词 | ABT-100;ABT-100 (ABT100);[1,1'-Biphenyl]-3-carbonitrile, 6-[(2S)-2-(4-cyanophenyl)-2-hydroxy-2-(1-methyl-1H-imidazol-5-yl)ethoxy]-4'-(trifluoromethoxy)- |
CAS号 | 450839-40-4 |
分子式 | C27H19F3N4O3 |
分子量 | 504.46 |
EINECS号 | |
相关类别 | |
Mol文件 | 450839-40-4.mol |
结构式 |
ABT-100 性质
沸点 | 722.0±60.0 °C(Predicted) |
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密度 | 1.29±0.1 g/cm3(Predicted) |
储存条件 | -20°C, protect from light |
形态 | 固体 |
酸度系数(pKa) | 12.15±0.29(Predicted) |
颜色 | 白色至米白色 |
Farnesyltransferase
ABT-100 (0.1-100 nM; 7 days; EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells) treatment shows dose-dependent growth inhibition of human cancer cell lines. Also inhibits colony formation at concentrations comparable with which ABT-100 inhibits anchorage-dependent growth.
Cell Proliferation Assay
Cell Line: | EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells |
Concentration: | 0.1-100 nM |
Incubation Time: | 7 days |
Result: | Demonstrated dose-dependent growth inhibition of human cancer cell lines. |
ABT-100 (6.25-12.5 mg/kg/day; subcutaneous injection; daily; for 21 days; C.B-17 scid male mice) treatment regresses EJ-1 tumors in mice.
Animal Model: | C.B-17 scid male mice with EJ-1 cells |
Dosage: | 6.25 mg/kg/day, 12.5 mg/kg/day |
Administration: | Subcutaneous injection; daily; for 21 days |
Result: | Regressed EJ-1 tumors in C.B-17 scid male mice. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-119257 | ABT-100 | 1 mg | 1000元 | |
2024/08/19 | HY-119257 | ABT-100 ABT-100 | 450839-40-4 | 5mg | 3600元 |