|
|
| | 5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide Basic information |
| Product Name: | 5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide | | Synonyms: | 5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide;GRL-0617
(GRL0617;Benzamide, 5-amino-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]-;GRL 0617,competitive noncovalent inhibitor,Inhibitor,GRL0617,Deubiquitinase,SARS coronavirus,inhibit,GRL-0617,DUBs,SARS-CoV;(R)-5-Amino-2-methyl-N-(1-(naphthalen-1-yl)ethyl)benzamide;5-Amino-2-Methyl-N-[(1r)-1-Naphthalen-1-Ylethyl]benzamide | | CAS: | 1093070-16-6 | | MF: | C20H20N2O | | MW: | 304.39 | | EINECS: | | | Product Categories: | | | Mol File: | 1093070-16-6.mol |  |
| | 5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide Chemical Properties |
| Boiling point | 514.9±50.0 °C(Predicted) | | density | 1.168±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | solubility | Soluble in DMSO (>30 mg/mL) and ethanol (15 mg/mL) | | form | solid | | pka | 14.26±0.46(Predicted) | | color | Beige | | Stability: | Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| | 5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide Usage And Synthesis |
| Description | GRL-0617 (1093070-16-6) is a potent (IC50?= 600 nM) noncovalent inhibitor of severe acute respiratory syndrome-coronavirus papain-like protease (SARS-CoV PLpro). GRL-0617 inhibited SARS-CoV viral replication in Vero E6 cells with no cytotoxicity (EC50?= 15 μM).??Inactive against human DUB-like proteases HAUSP, USP18, UCH-L1, UCH-L3, and PLP2 | | Definition | ChEBI: GRL-0617 is a benzamide resulting from the formal condensation of the carboxy group of 5-amino-2-methylbenzoic acid with the amino group of (1R)-1-(naphthalen-1-yl)ethan-1-amine. It is a potent noncovalent inhibitor (IC50 = 600 nM) of severe acute respiratory syndrome-coronavirus papain-like protease (SARS-CoV PLpro). It has a role as an anticoronaviral agent and a protease inhibitor. It is a member of naphthalenes, a substituted aniline, a member of benzamides and a secondary carboxamide. | | storage | Store at -20°C | | References | 1)????Ratia?et al. (2008),?A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication;?Proc. Natl. Acad. Sci. USA,?105?16119 |
| | 5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide Preparation Products And Raw materials |
|