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| Product Name: | 3PO | | Synonyms: | 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one;2-Propen-1-one, 3-(3-pyridinyl)-1-(4-pyridinyl)-;(E)3PO,(E) 3PO | | CAS: | 13309-08-5 | | MF: | C13H10N2O | | MW: | 210.23 | | EINECS: | | | Product Categories: | | | Mol File: | 13309-08-5.mol |  |
| Melting point | 144-147°C | | Boiling point | 387.8±42.0 °C(Predicted) | | density | 1.192±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | pka | 4.20±0.12(Predicted) | | form | Solid | | color | Pale Yellow to Yellow |
| Uses | 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one inhibits human bladder cancer cell lines growth. It also inhibits cancer cell growth proliferation by it’s treatment in combination with phenoformin. An inhibitor of 6-phosphofructo-2- kinaselfructose-2,6-bisphosphatase 3 (PFKFB). | | Definition | ChEBI: 3PO is a member of the class of pyridines that is pyridine substituted by a 3-oxo-3-(pyridin-4-yl)prop-1-en-1-yl group at position 3. An inhibitor of PFKFB3 kinase, an enzyme with a key role in glycolysis. It has a role as an antineoplastic agent, an angiogenesis inhibitor, an autophagy inducer, an apoptosis inducer and an EC 2.7.1.105 (6-phosphofructo-2-kinase) inhibitor. It is a member of pyridines and an enone. | | storage | Store at -20°C |
| | 3PO Preparation Products And Raw materials |
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