| Company Name: |
MedChemexpress LLC
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| Tel: |
021-58955995 |
| Email: |
sales@medchemexpress.cn |
| Products Intro: |
Product Name:KIN1408
Purity:>98% Package:1500RMB/1mg
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| | KIN1408 Basic information |
| Product Name: | KIN1408 | | Synonyms: | KIN1408;7-((4-(difluoromethoxy)phenyl)((5-methoxybenzo[d]thiazol-2-yl)amino)methyl)quinolin-8-ol);KIN-1408
(KIN-1408;KIN-1408;KIN 1408;7-((4-(DIFLUOROMETHOXY)PHENYL)((5-METHOXYBENZO[D]THIAZOL-2-YL)AMINO)METHYL)QUINOLIN-8-OL;8-Quinolinol, 7-[[4-(difluoromethoxy)phenyl][(5-methoxy-2-benzothiazolyl)amino]methyl]-;KIN1408 >=98% (HPLC) | | CAS: | 1903800-11-2 | | MF: | C25H19F2N3O3S | | MW: | 479.5 | | EINECS: | | | Product Categories: | | | Mol File: | 1903800-11-2.mol |  |
| | KIN1408 Chemical Properties |
| Boiling point | 675.6±65.0 °C(Predicted) | | density | 1.430±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:34.5(Max Conc. mg/mL);71.95(Max Conc. mM) | | form | A solid | | pka | 4.22±0.50(Predicted) | | color | Light yellow to yellow |
| | KIN1408 Usage And Synthesis |
| Description | KIN1408 is a small molecule activator of the RIG-1-like receptor (RLR) pathway that has antiviral activity. It induces interferon regulatory factor 3 (IRF3) activation and translocation into the nucleus in a concentration-dependent manner in HEK293 cells without inducing cellular toxicity. KIN1408 induces expression of the innate immune genes MDA5, RIG-1, Mx1, IRF7, and IFIT1 in THP-1 cells stimulated with phorbol 12-myristate 12-acetate (PMA; ). It exhibits concentration-dependent broad-spectrum antiviral activity against dengue virus 2 as well as the influenza A, Ebola, Nipah, and Lassa viruses. |
| | KIN1408 Preparation Products And Raw materials |
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