|
|
| | KJ Pyr 9 Basic information |
| Product Name: | KJ Pyr 9 | | Synonyms: | KJ Pyr 9;KJ Pyrq;Benzamide, 4-[2-(2-furanyl)-6-(4-nitrophenyl)-4-pyridinyl]-;4-[2-(2-Furanyl)-6-(4-nitrophenyl)-4-pyridinyl]benzamide;c-Myc,KJ Pyr9,inhibit,Autophagy,Inhibitor,Myc,KJ Pyr 9,KJ Pyr-9;4-(2-(Furan-2-yl)-6-(4-nitrophenyl)pyridin-4-yl)benzamide;4-[2-(2-Furyl)-6-(4-nitrophenyl)-4-pyridyl]benzamide | | CAS: | 581073-80-5 | | MF: | C22H15N3O4 | | MW: | 385.37 | | EINECS: | | | Product Categories: | | | Mol File: | 581073-80-5.mol |  |
| | KJ Pyr 9 Chemical Properties |
| Boiling point | 584.4±50.0 °C(Predicted) | | density | 1.320±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | ≤20mg/ml in DMSO;25mg/ml in dimethyl formamide | | form | crystalline solid | | pka | 15.34±0.50(Predicted) | | color | Light yellow to yellow |
| | KJ Pyr 9 Usage And Synthesis |
| Uses | 4-[2-(2-Furanyl)-6-(4-nitrophenyl)-4-pyridinyl]benzamide is a inhibits MYC-induced oncogenic transformation in cell culture and blocks the growth of a xenotransplant of MYC-amplified human cancer cells. | | Biological Activity | mkj pyr 9 is a novel small molecule inhibitor of myc, with the kd value of 6.5 ± 1.0 nm. besides, kj pyr 9 also suppresses the formation of myc-max and oncogenic transformation induced by myc in cell culture [1]. | | in vitro | in chicken embryo fibroblasts, kj pyr 9 was found to have the ability to interfere with the oncogenic activity of myc, with the best aqueous solubility. besides, in human b-cell line p493-6, 20 μm kj pyr 9 could significantly inhibit cell proliferation, and kj pyr 9 could also inhibit the proliferation of nci-h460, mda-mb-231, and sum-159pt cell lines, with the ic50 values between 5-10 μm. furthermore, treatment of p493-6 cells with kj pyr 9 could significantly suppress the transcription ability of myc [1]. | | in vivo | kj pyr 9 was found to have no acute toxicity in mouse and rat at a dose of 10 mg/kg, with an impressive ability to cross the blood-brain barrier. besides, in a mda-mb-231 cells xenograft tumor nude mice model, intraperitoneal injection with 10 mg/kg kj pyr 9 for 31 days could significantly inhibit tumor growth, while having no effect on the body weight [1]. | | target | myc | | storage | Store at +4°C | | references | [1] hart j r, garner a l, yu j, et al. inhibitor of myc identified in a kröhnke pyridine library[j]. proceedings of the national academy of sciences, 2014, 111(34): 12556-12561. |
| | KJ Pyr 9 Preparation Products And Raw materials |
|