| Company Name: |
Haoyuan Chemexpress Co., Ltd.
|
| Tel: |
021-58950125 |
| Email: |
info@chemexpress.com |
| Products Intro: |
Product Name:CGP 25454A
CAS:104391-26-6
Purity:>98% Package:1500RMB/1mg
|
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Email: |
info@musechem.com |
| Products Intro: |
Product Name:CGP 25454A
CAS:104391-26-6
Purity:>98% HPLC Package:10mg;100mg;1g Remarks:Reagent Grade
|
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Email: |
sales@dcchemicals.com |
| Products Intro: |
Product Name:CGP-25454A
CAS:104391-26-6
Purity:98% HPLC Package:100mg，250mg，1g
|
|
| | CGP 25454A Basic information |
| | CGP 25454A Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO : ≥ 3.5 mg/mL (10.11 mM) | | form | Solid | | color | White to off-white |
| | CGP 25454A Usage And Synthesis |
| Biological Activity | CGP 25454A is a novel and selective presynaptic dopamine autoreceptor antagonist. | | in vitro | CGP 25454A increase the field-stimulated [3H]- and [14C]-overflow from rat striatal slices preloaded with [3H]dopamine and [14C]choline, indicating that CGP 25454A is able to enhance the release of both dopamine (DA) and acetylcholine (ACh). However, CGP 25454A is 12.9 times more potent in increasing, by 1/6 of the apparent maximal increase, the release of [3H]DA than that of [14C]ACh. | | in vivo | CGP 25454A increase [3H]spiperone binding to receptors of the D2 family in rat striatum by 90-110% (ED50: 13 mg/kg i.p.). As a similar increase in [3H]spiperone binding is found with a variety of agents which increase the synaptic concentration of endogenous DA, the effect of CGP 25454A most probably reflects an enhanced release of DA under in vivo conditions. At 30-100 mg/kg, CGP 25454A inhibit [3H]spiperone binding in the pituitary of the same animals as a result of a blockade of postsynaptic DA receptors. |
| | CGP 25454A Preparation Products And Raw materials |
|