PTP1B-IN-9
| 中文名称 | PTP1B-IN-9 |
|---|---|
| 中文同义词 | 化合物PTP1B-IN-9;3,5-双(3,4-二氯亚苄基)哌啶-4-酮 |
| 英文名称 | (3E,5E)-3,5-Bis(3,4-Dichlorobenzylidene)Piperidin-4-One |
| 英文同义词 | (3E,5E)-3,5-Bis(3,4-Dichlorobenzylidene)Piperidin-4-One;3,5-Bis(3,4-dichlorobenzylidene)piperidin-4-one;RAMB4;4-Piperidinone, 3,5-bis[(3,4-dichlorophenyl)methylene]-;(3E,5E)-3,5-Bis(3,4-Dichlorobenzylidene)Piperidin-4-One(WXC02309);PTP1B-IN-9?;RAMB4( PTP1B-IN-9);inhibit,cancer,Proteasome,RAMB4,stress,degradation,Ubiquitin,RAMB 4,Inhibitor,response,cells,HeLa,RAMB-4,cervical |
| CAS号 | 145888-79-5 |
| 分子式 | C19H13Cl4NO |
| 分子量 | 413.12 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 145888-79-5.mol |
| 结构式 |  |
PTP1B-IN-9 性质
| 沸点 | 607.5±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.463±0.06 g/cm3(Predicted) |
| 储存条件 | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| 溶解度 | 二甲基亚砜：5 mg/mL（12.10 mM） |
| 形态 | 固体 |
| 酸度系数(pKa) | 6.43±0.20(Predicted) |
| 颜色 | 浅黄至黄色 |
PTP1B-IN-9用作研究用化合物。
PTP1B-IN-9 是通过抑制 20S 蛋白酶体催化活性物质上游泛素介导的蛋白质降解而产生的泛素-蛋白酶体系统 (UPS) 应激源。PTP1B-IN-9 在不影响 20S 蛋白酶体催化活性的情况下触发泛素蛋白酶体系统 (UPS) 应激反应。
PTP1B-IN-9 (0-30 µM; 48 hours) treatment produces a dose dependent reduction in the viability of HPV16-positive SiHa and Caski cells and HPV-39-positive ME180 cervical cancer cell lines respectively.
PTP1B-IN-9 reduces the cell viability of exponentially growing HeLa cervical cancer cells in a dose-dependent fashion with an IC
50
value of 2 µM.
Cell Viability Assay
| Cell Line: | Keratinocytes, SiHa, CaSki and ME180 cells |
| Concentration: | 5, 10, 15, 20, 25, 30 µM |
| Incubation Time: | 48 hours |
| Result: | Produced a dose dependent reduction in the viability of HPV16-positive SiHa and Caski cells and HPV-39-positive ME180 cervical cancer cell lines respectively with minimal effects on the viability of primary human keratinocytes and with IC 50 similar to the obtained with HeLa cells. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-W054146 | RAMB4 | 5 mg | 562元 | |
| 2024/08/19 | HY-W054146 | PTP1B-IN-9 RAMB4 | 145888-79-5 | 10mg | 900元 |