| Company Name: |
BOC Sciences
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info@bocsci.com |
| Products Intro: |
Product Name:MHY 908
CAS:1393371-39-5
Purity:99% Remarks:MHY 908 is a dual PPARα/γ agonist and a melanogenesis inhibitor that suppresses mushroom tyrosinase activity (IC50 value 8.19 μM). MHY908 exhibits more potent activation of PPARα and PPARγ than fenofi
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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sales@chemegen.com |
| Products Intro: |
Product Name:MHY908
CAS:1393371-39-5
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| | MHY 908 Basic information |
| Product Name: | MHY 908 | | Synonyms: | MHY 908;MHY908,MHY-908;Propanoic acid, 2-[4-(5-chloro-2-benzothiazolyl)phenoxy]-2-methyl- | | CAS: | 1393371-39-5 | | MF: | C17H14ClNO3S | | MW: | 347.82 | | EINECS: | | | Product Categories: | | | Mol File: | 1393371-39-5.mol |  |
| | MHY 908 Chemical Properties |
| Boiling point | 523.6±58.0 °C(Predicted) | | density | 1.381±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:8): 0.1 mg/ml; DMSO: 10 mg/ml; Ethanol: 1 mg/ml | | form | A crystalline solid | | pka | 3.15±0.10(Predicted) |
| | MHY 908 Usage And Synthesis |
| Description | MHY908 is a dual agonist of peroxisome proliferator-activated receptor α (PPARα) and PPARγ that increases transcriptional activity of PPARα and PPARγ in a luciferase reporter assay in AC2F rat liver cells when used at a concentration of 5 μM. In vivo, MHY908 (3 mg/kg per day) reduces serum glucose, triglyceride, and insulin levels and improves hepatic steatosis by reducing hepatic triglyceride levels and lipid droplet accumulation in db/db mice and 20-month-old rats. It reduces peroxynitrite and COX-2 levels, reactive oxygen species (ROS) production, and Akt phosphorylation in isolated kidney from 20-month-old rats when administered at a dose of 3 mg/kg. MHY908 inhibits mushroom tyrosinase (IC50 = 8.19 μM). It also inhibits increases in melanin content in α-melanocyte stimulating hormone-induced B16/F10 murine melanoma cells when used at a concentration of 10 μM. | | Uses | MHY908 is a dual agonist of PPARα and PPARγ. |
| | MHY 908 Preparation Products And Raw materials |
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