| Company Name: |
Shanghai Chaolan Chemical Technology Center
|
| Tel: |
QQ:65489617 15618227136 |
| Email: |
info@SuperLan-chem.com |
| Products Intro: |
Product Name:MMPIP hydrochloride
CAS:1215566-78-1
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G
|
|
| | MMPIP (hydrochloride) Basic information |
| Product Name: | MMPIP (hydrochloride) | | Synonyms: | 6-chloro-5-methyl-N-[6-(2-methylpyridin-3-yl)oxypyridin-3-yl]-2,3-dihydroindole-1-carboxamide;242084;CS-1472;CS-2104;SB-242084 HCl;MMPIP hydrochloride (479077-02-6 Free base);MMPIP hydrochloride,MMPIP,system,nervous,neuropathic,behavior,pain,inhibit,central,glutamate,cognitive,allosteric,Metabotropic glutamate receptors,Inhibitor,metabotropic,mGluR,mGluR7 | | CAS: | 1215566-78-1 | | MF: | C19H16ClN3O3 | | MW: | 369.802 | | EINECS: | | | Product Categories: | | | Mol File: | 1215566-78-1.mol |  |
| | MMPIP (hydrochloride) Chemical Properties |
| storage temp. | Desiccate at RT | | solubility | Soluble to 50 mM in DMSO | | form | Powder | | color | Light yellow to green yellow |
| | MMPIP (hydrochloride) Usage And Synthesis |
| Description | MMPIP is a reversible allosteric antagonist of the metabotropic glutamate receptor 7 (mGluR7) that blocks agonist-induced calcium mobilization (IC50 = 26 nM). It does not affect other mGlu receptors. The modulation of mGluR7 by MMPIP is context dependent, in that it is not observed in all known mGluR7 signaling pathways. MMPIP has been used to investigate the role of mGluR7 in cocaine-mediated reward signaling, attention and impulse control, and cognitive behavior in mice and rats. MMPIP also reversibly inhibits constitutive activity of mGluR7 in sympathetic neurons from the rat superior cervical ganglion. | | Uses | MMPIP Hydrochloride is a reversible allosteric antagonist of the metabotropic glutamate receptor 7 (mGluR7) that blocks agonist-induced calcium mobilization. | | Definition | ChEBI: 6-chloro-5-methyl-N-[6-(2-methylpyridin-3-yl)oxypyridin-3-yl]-2,3-dihydroindole-1-carboxamide;dihydrochloride is an organic molecular entity, an indole alkaloid and a pyridine. It has a role as a receptor modulator. |
| | MMPIP (hydrochloride) Preparation Products And Raw materials |
|