MX69
| 中文名称 | MX69 |
|---|---|
| 中文同义词 | MDM2/XIAP抑制剂(MX69);4-(8-((3,4-二甲基苯基)氨基磺酰基)-3A,4,5,9B-四氢-3H-环戊二烯并[C]喹啉-4-基)苯甲酸;化合物MX69 |
| 英文名称 | MX-69 |
| 英文同义词 | MX-69;CS-2402;MX69 (MX 69;Benzoic acid, 4-[8-[[(3,4-dimethylphenyl)amino]sulfonyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]-;E1/E2/E3 Enzyme,inhibit,E3 ligating enzyme,MX 69,Ubiquitin ligase,IAP,MX69,E1 activating enzyme,E2 conjugating enzyme,Ubiquitin conjugating enzyme,MX-69,Inhibitor,Ubiquitin activating enzyme,MDM-2/p53;4-(8-(N-(3,4-Dimethylphenyl)sulfamoyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl)benzoic acid |
| CAS号 | 1005264-47-0 |
| 分子式 | C27H26N2O4S |
| 分子量 | 474.57 |
| EINECS号 | |
| 相关类别 | 抑制剂;细胞生物学试剂 |
| Mol文件 | 1005264-47-0.mol |
| 结构式 |  |
MX69 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 可溶于DMSO |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
MX69 是一种 MDM2/XIAP 抑制剂，常用于抗癌研究。
MX69 blocks the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation. MX69 shows minimal inhibitory effect on normal human hematopoiesis in vitro and is very well tolerated in animal models. MX69-induced MDM2 downregulation results not only in inhibition of XIAP expression, but also in activation of p53, which contributes to cancer cell apoptosis in vitro.
MX69-induced MDM2 downregulation results in activation of p53 which contributes to inhibition of cancer cell proliferation in vivo.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-100892 | MX69 MX69 | 1005264-47-0 | 5mg | 700元 |
| 2024/08/19 | HY-100892 | MX69 MX69 | 1005264-47-0 | 10mM * 1mLin DMSO | 730元 |