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MedChemexpress LLC
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Product Name:BPO-27 (racemate)
CAS:1314873-02-3
Purity:>98% Package:1500RMB/1mg
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BPO-27 (racemate) manufacturers
- BPO-27 racemate
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- $39.00 / 1mg
-
2024-11-19
- CAS:1314873-02-3
- Min. Order:
- Purity: 98.19%
- Supply Ability: 10g
- BPO-27 racemate
-
- $39.00 / 1mg
-
2024-11-19
- CAS:1314873-02-3
- Min. Order:
- Purity: 98.19%
- Supply Ability: 10g
|
| | BPO-27 (racemate) Basic information |
| Product Name: | BPO-27 (racemate) | | Synonyms: | BPO-27 (racemate);BPO 27 RACEMATE; BPO27 RACEMATE;BPO-27 racemat;6H-Pyrimido[4',5':3,4]pyrrolo[2,1-c][1,4]benzoxazine-2-carboxylic acid, 6-(5-bromo-2-furanyl)-7,8,9,10-tetrahydro-7,9-dimethyl-8,10-dioxo-11-phenyl-;Inhibitor,Cystic fibrosis transmembrane conductance regulator,inhibit,BPO27 racemate,Autophagy,BPO-27,BPO 27,BPO 27 racemate,BPO27,CFTR;6-(5-bromofuran-2-yl)-7,9-dimethyl-8,10-dioxo-11-phenyl-7,8,9,10-tetrahydro-6H-benzo[b]pyrimido[4',5':3,4]pyrrolo[1,2-d][1,4]oxazine-2-carboxylic acid;BPO-27 racemate, 10 mM in DMSO | | CAS: | 1314873-02-3 | | MF: | C26H18BrN3O6 | | MW: | 548.34 | | EINECS: | | | Product Categories: | | | Mol File: | 1314873-02-3.mol |  |
| | BPO-27 (racemate) Chemical Properties |
| Boiling point | 732.9±70.0 °C(Predicted) | | density | 1.68±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 6 mg/mL (10.94 mM) | | form | Solid | | pka | 3.76±0.40(Predicted) | | color | White to off-white |
| | BPO-27 (racemate) Usage And Synthesis |
| Uses | BPO-27 racemate is a potent CFTR inhibitor with an IC50 of 8 nM. | | in vivo | Following bolus interperitoneal administration in mice, serum (R)-1 decays with t1/2 ≈ 1.6 h and gives sustained therapeutic concentrations in kidney[1]. | | References | [1] Snyder DS, et al. Absolute Configuration And Biological Properties of Enantiomers of CFTR Inhibitor BPO-27. ACS Med Chem Lett. 2013 May 9;4(5):456-459. DOI:10.1021/ml400069k
[2] Kim Y, et al. Benzopyrimido-pyrrolo-oxazine-dione (R)-BPO-27 Inhibits CFTR Chloride Channel Gating by Competition with ATP. Mol Pharmacol. 2015 Oct;88(4):689-96. DOI:10.1124/mol.115.098368 |
| | BPO-27 (racemate) Preparation Products And Raw materials |
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