Stampidine
| 中文名称 | Stampidine |
|---|---|
| 中文同义词 | 化合物 T24839;化合物 STAMPIDINE |
| 英文名称 | Stampidine |
| 英文同义词 | Stampidine;Sampidine;HI 113 |
| CAS号 | 217178-62-6 |
| 分子式 | C20H23BrN3O8P |
| 分子量 | 544.289681 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 217178-62-6.mol |
| 结构式 |  |
Stampidine 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | DMSO：100 mg/mL（183.73 mM；需要超声波） |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
IC50: 1 nM (HTLV IIIB ), 2 nM (primary clinical isolates), 8.7 nM (NRTI-resistant primary clinical isolates), 11.2 nM (NRTI-resistant primary clinical isolates)
Stampidine (7.8-1,000 μM; 24 hours) is not cytotoxic to genital tract epithelial cells.
Stampidine has no effect on sperm motility in cervical mucus.
Stampidine (50-100 mg/kg; p.o.) exhibits potent antiretroviral activity in chronically feline immunodeficiency virus (FIV)-infected cats.
Stampidine (100 mg/kg; p.o.) shows the average plasma C
max
, AUC, half-life (t
1/2
), and mean residence time (MRT) values of 15.4 µM, 23.1 µM•h, 108.6 min and 119.4 min, respectively, in dogs.
Stampidine does not cause anemia, thrombocytopenia, neutropenia, or lymphopenia suggestive of hematologic toxicity, elevations of BUN or creatinine or electrolyte disturbances suggestive of renal toxicity or metabolic abnormalities, elevations of ALT, AST, Alk in adult beagle dogs.
| Animal Model: | SPF male or female domestic cats (2.9- 6.2 kg), with chronically FIV-infected |
| Dosage: | 50 mg/kg, 100 mg/kg |
| Administration: | Oral administration (oral bolus dose) |
| Result: | Exhibited potent antiretroviral activity. |
| Animal Model: | Male beagle dogs (10-12 kg) |
| Dosage: | 100 mg/kg (Pharmacokinetic Analysis) |
| Administration: | Oral administration |
| Result: | The estimated average plasma C max and AUC values were 15.4 µM and 23.1 µM·h, respectively. The average elimination half-life (t 1/2 ) and mean residence time (MRT) were 108.6 min and 119.4 min, respectively. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-122470 | Stampidine | 1 mg | 1818元 | |
| 2024/11/08 | HY-122470 | Stampidine Stampidine | 217178-62-6 | 5mg | 4000元 |