| Company Name: |
Riedel-de Haen AG
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| Tel: |
800 558-9160 |
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| Products Intro: |
Purity:purified immunoglobulin, buffered aqueous solution Remarks:IgG fraction of antiserum, buffered aqueous solution
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| Company Name: |
SIGMA-RBI
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| Tel: |
800 736 3690 (Orders) |
| Email: |
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| Products Intro: |
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| | ANTI-TSG101-ASSOCIATED LIGASE Basic information |
| Product Name: | ANTI-TSG101-ASSOCIATED LIGASE | | Synonyms: | ANTI-TAL (CS-15);ANTI-TAL (FQ-17);ANTI-TSG101-ASSOCIATED LIGASE;Anti-Tal (FQ-17) antibody produced in rabbit;Anti-Tal (CS-15) antibody produced in rabbit;Anti-E3 ubiquitin-protein ligase LRSAM1;Anti-hTAL;Anti-Leucine-rich repeat and sterile alpha motif-containing protein 1 | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-TSG101-ASSOCIATED LIGASE Structure]() |
| | ANTI-TSG101-ASSOCIATED LIGASE Chemical Properties |
| storage temp. | −20°C | | form | buffered aqueous solution |
| | ANTI-TSG101-ASSOCIATED LIGASE Usage And Synthesis |
| Uses | Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper) | | Uses | All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit . | | General Description | LRSAM1 is a multifunctional RING finger protein that selectively regulates cell adhesion molecules, has ubiquitin ligase activity, and plays a role in receptor endocytosis and viral budding (Li et al., 2003 [PubMed 14635195]; Amit et al., 2004 [PubMed 15256501]).[supplied by OMIM | | Biochem/physiol Actions | Tsg101-associated ligase (TAL) plays a key role in cell signaling, cell adhesion and regulates cargo sorting. Reduced expression of Tsg101 shunts active epidermal growth factor receptor (EGFRs) from the normal degradative pathway to a recycling route. Tal, which interacts with Tsg101 associates with and ubiquitylates Tsg101 in a manner that regulates receptor trafficking and budding of viral particles. Tal binds to Tsg101 in a bimodal mode, through an interaction of its CC domain with the steadiness box (SB) of Tsg101, and also via binding of the UEV domain of Tsg101 with two PTAP motifs just upstream of the C-terminal RING domain. Tal interaction with Tsg101 promotes multiple monoubiquitination of Tsg101, rather than polyubiquitination, which leads to the release of Tsg101 from membrane complexes and its inactivation. Mutations in the TAL gene is implicated in Charcot-Marie-Tooth (CMT) syndrome. |
| | ANTI-TSG101-ASSOCIATED LIGASE Preparation Products And Raw materials |
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