| Company Name: |
Guangzhou Isun Pharmaceutical Co., Ltd
|
| Tel: |
020-39119399 18927568969 |
| Email: |
isunpharm@qq.com |
| Products Intro: |
Product Name:A-971432
CAS:1240308-45-5
Purity:95% (HPLC) Package:5MG; 25MG; 100MG; 1G
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:A-971432
CAS:1240308-45-5
Purity:>=95% (HPLC) Package:5MG Remarks:SML1744-5MG
|
| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
|
| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:A-971432
CAS:1240308-45-5
Purity:>98% Package:1mg;10mg;50mg;100mg;
|
|
| | A971432 Basic information |
| Product Name: | A971432 | | Synonyms: | A971432;1-[[4-[(3,4-Dichlorophenyl)methoxy]phenyl]methyl]-3-azetidinecarboxylic acid;1-(4-((3,4-dichlorobenzyl)oxy)benzyl)azetidine-3-carboxylic acid;A-971432 >=95% (HPLC);A971432,A 971432;3-Azetidinecarboxylic acid, 1-[[4-[(3,4-dichlorophenyl)methoxy]phenyl]methyl]-;1-({4-[(3,4-dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acid | | CAS: | 1240308-45-5 | | MF: | C18H17Cl2NO3 | | MW: | 366.24 | | EINECS: | 827-461-8 | | Product Categories: | | | Mol File: | 1240308-45-5.mol |  |
| | A971432 Chemical Properties |
| Boiling point | 520.0±50.0 °C(Predicted) | | density | 1.402±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Slightly soluble in chloroform | | form | powder | | pka | 2.70±0.20(Predicted) | | color | white to beige |
| | A971432 Usage And Synthesis |
| Uses | A 971432 is used in the preparation of benzylazetidinecarboxylate derivatives as agonists and antagonists of the S1P5 receptor. | | Biochem/physiol Actions | A-971432 is an orally bioavailable, non-clastogenic, azetidinecarboxylate compound that acts as a highly potent and selective sphingosine-1-phosphate receptor 5 agonist (IC50?= 6 nM/S1P5, 362 nM/S1P1 and >10 μM/S1P3 in a radio-ligand binding assay) without affect the activity of 129 protein kinases (IC50?>10 μM). A-971432 is shown to enhance blood-brain barrier integrity and reverse lipid accumulation and age-related cognitive decline in mice in vivo with good pharmacokinetics (t1/2??= 5.7 h; Cmax?= 2,500 ng/ml; AUC = 35,000 ng.h/ml at 10 mg/kg, p.o. in CD1 mice). Likewise, oral gavage showed good plasma exposure and no sign of lymphopenia in rats (10, 30, and 100 mg/kg. | | storage | Store at RT |
| | A971432 Preparation Products And Raw materials |
|