Company Name: |
TargetMol Chemicals Inc.
|
Tel: |
4008200310 |
Email: |
marketing@tsbiochem.com |
Products Intro: |
Product Name:IWP-051;IWP 051 CAS:1354041-91-0 Purity:98% Package:5 mg
|
|
| IWP-051 Basic information |
Product Name: | IWP-051 | Synonyms: | IWP-051;4(3H)-Pyrimidinone, 5-fluoro-2-[1-[(2-fluorophenyl)methyl]-5-(3-isoxazolyl)-1H-pyrazol-3-yl]- | CAS: | 1354041-91-0 | MF: | C17H11F2N5O2 | MW: | 355.3 | EINECS: | | Product Categories: | | Mol File: | 1354041-91-0.mol | ![IWP-051 Structure](CAS/20210305/GIF/1354041-91-0.gif) |
| IWP-051 Chemical Properties |
density | 1.53±0.1 g/cm3(Predicted) | pka | 5.03±0.50(Predicted) |
| IWP-051 Usage And Synthesis |
Description | IWP-051 is a potent, orally active sGC stimulator (EC50 = 290nM). IWP-051 showed >99% plasma protein binding, high metabolic stability, high permeability, and no efflux in a Caco-2 model of intestinal absorption. IWP-051 achieves good alignment of potency, stability, selectivity, and pharmacodynamic effects while maintaining favorable pharmacokinetic properties with once-daily dosing potential in humans. |
| IWP-051 Preparation Products And Raw materials |
|