878143-03-4
中文名称 | 878143-03-4 |
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中文同义词 | 化合物 T12452;二甘酯双磷酸钠 |
英文名称 | Phosphonic acid, [(3E)-1-[(2E)-3,7-dimethyl-2,6-octadienyl]-4,8-dimethyl-3,7-nonadienylidene]bis-, tetrasodium salt |
英文同义词 | Phosphonic acid, [(3E)-1-[(2E)-3,7-dimethyl-2,6-octadienyl]-4,8-dimethyl-3,7-nonadienylidene]bis-, tetrasodium salt;DGBP;Digeranyl bisphophonate;Digeranyl bisphosphonate |
CAS号 | 878143-03-4 |
分子式 | C21H39NaO6P2 |
分子量 | 472.47 |
EINECS号 | |
相关类别 | |
Mol文件 | 878143-03-4.mol |
结构式 |
878143-03-4 性质
储存条件 | Store at -20°C, protect from light, stored under nitrogen |
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溶解度 | DMSO:2 mg/mL(3.73 mM;需要超声波)| |
形态 | 固体 |
颜色 | 白色至米白色 |
水溶解性 | Water : 2 mg/mL (3.73 mM; Need ultrasonic) |
Rac1
Digeranyl bisphosphonate (DGBP) impairs geranylgeranylation. To examine if Digeranyl bisphosphonate modulates Rac1 activity, cells are exposed to vehicle or Digeranyl bisphosphonate. Rac1 activation increases significantly after chrysotile exposure, whereas the activity in Digeranyl bisphosphonate -treated cells is reduced to control levels. Digeranyl bisphosphonate also decreases H 2 O 2 generation in chrysotile-exposed macrophages.
To further evaluate the effect of Digeranyl bisphosphonate (DGBP; 0.2 mg/kg/day) in protecting mice from chrysotile-induced pulmonary fibrosis, the mice are administered vehicle or Digeranyl bisphosphonate subcutaneously in osmotic pumps, and exposed to saline or chrysotile the following day. Mice exposed to saline have normal lung architecture with vehicle and Digeranyl bisphosphonate treatment. Chrysotile-exposed mice that receive vehicle have significant architectural changes in their lung parenchyma and large amounts of collagen deposition, whereas the lungs of the Digeranyl bisphosphonate -treated mice are essentially normal. To investigate the effect of Digeranyl bisphosphonate in Bleomycin-induced fibrosis, osmotic pumps containing either vehicle or Digeranyl bisphosphonate are implanted subcutaneously in WT mice. Mice are exposed to saline or Bleomycin the following day. Digeranyl bisphophonate (0.2 mg/kg/day)-treated mice show significantly less hydroxyproline compared to vehicle-treated mice exposed to Bleomycin.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-U00145 | 878143-03-4 Digeranyl bisphosphonate | 878143-03-4 | 1mg | 3200元 |
2024/08/19 | HY-U00145 | 878143-03-4 Digeranyl bisphosphonate | 878143-03-4 | 5mg | 6400元 |