Log in | Join Free | china | japan | germany

1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide

Request For Quotation
1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: CAS:1917294-46-2
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:PF-04745637；PF 4745637;PF-4745637;PF 04745637;PF4745637;PF04745637
CAS:1917294-46-2
Package:1 mg；10 mg；100 mg；200 mg；25 mg；5 mg；50 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Products Intro: Product Name:4-bromo-2,5-dimethoxybenzene-1-sulfonyl chloride
CAS:1917294-46-2
Purity:99% Package:5KG;1KG Remarks:4-bromo-2,5-dimethoxybenzene-1-sulfonyl chloride
Company Name: Shanghai Lollane Biological Technology Co.,Ltd.  
Tel: 021-52996696，15000506266 15000506266
Email:
Products Intro: Product Name:PF-04745637
CAS:1917294-46-2
Purity:98% HPLC Package:5mg，10mg，50mg，100mg，1g，5g
Company Name: ShangHai Angti Biotechnology Co., Ltd.  
Tel: 13764913901
Email: info@angtibio.com
Products Intro: Product Name:1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide
CAS:1917294-46-2
Purity:95% HPLC
1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide Basic information
Product Name:1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide
Synonyms:1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide;PF-4745637;PF4745637;PF 4745637;1-(4-Chlorophenyl)- N-[2-[4-hydroxy-4-(trifluoromethyl)-1-piperidinyl]-3-phenylpropyl]cyclopentanecarboxamide;PF-04745637;PF-04746537;PF04745637,Inhibitor,bowel,TRPA1,disease,inhibit,respiratory,PF-04745637,Transient receptor potential channels,inflammatory,TRP Channel,skin
CAS:1917294-46-2
MF:C27H32ClF3N2O2
MW:509.0033896
EINECS:
Product Categories:
Mol File:1917294-46-2.mol
1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide Structure
1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide Chemical Properties
Boiling point 651.8±55.0 °C(Predicted)
density 1.281±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
pka12.14±0.20(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide Usage And Synthesis
Biological ActivityPF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM for human TRPA1[1]. Topically applied PF-04745637 (Compound 8; 50 mg/mL and 100 mg/mL) significantly reduces cinnamaldehyde-mediated flare in rat skin[1].
References[1]. Laurie B. Schenkel, et al. The discovery of a potent series of carboxamide TRPA1 antagonists. J. Med. Chem. 2016, 59, 6, 2794-2809.
1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide Preparation Products And Raw materials
Tag:1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide(1917294-46-2) Related Product Information