1905453-18-0
| 中文名称 | 1905453-18-0 |
|---|---|
| 中文同义词 | UHRF1抑制剂(NSC232003);化合物NSC232003;5-(1-(羟基氨基)亚乙基)嘧啶-2,4(3H,5H)-二酮 |
| 英文名称 | NSC232003 |
| 英文同义词 | NSC232003;5-(1-(Hydroxyamino)ethylidene)pyrimidine-2,4(3H,5H)-dione;E2 conjugating enzyme,Ubiquitin activating enzyme,Inhibitor,NSC 232003,inhibit,E1 activating enzyme,Ubiquitin conjugating enzyme,E1/E2/E3 Enzyme,E3 ligating enzyme,NSC232003,Ubiquitin ligase,NSC-232003;2,4(3H,5H)-Pyrimidinedione, 5-[1-(hydroxyamino)ethylidene]- |
| CAS号 | 1905453-18-0 |
| 分子式 | C6H7N3O3 |
| 分子量 | 169.14 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂 |
| Mol文件 | 1905453-18-0.mol |
| 结构式 |  |
1905453-18-0 性质
| 密度 | 1.60±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | 水：17 mg/mL (100.51 mM)；DMSO：< 1 mg/mL（不溶或微溶） |
| 形态 | 固体 |
| 酸度系数(pKa) | 9.32±0.20(Predicted) |
| 颜色 | 白色至米白色 |
UHRF1
NSC232003, a uracil derivative freely available by the NCI/DTP repository, provides a versatile lead for developing highly potent and cell-permeable UHRF1 inhibitors that will enable dissection of DNA methylation inheritance. NSC232003 is indeed an effective DNA methylation inhibitor and indicate that this particular nucleotide scaffold could provide a versatile basis for the design of potent UHRF1 inhibitors. NSC232003 is predicted to be partially deprotonated at pH 7, as the pK a of the more acidic imide nitrogen of the pyrimidine ring is a value of 7.6 in NSC232003. The DNMT1/UHRF1 interactions are significantly reduced after 4 h of incubation of U251 glioma cells with the most potent compound NSC232003, showing a 50% interaction inhibition at 15 μM as well as induction of global DNA cytosine demethylation as measured by ELISA.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-103236 | 1905453-18-0 NSC232003 | 1905453-18-0 | 1mg | 790元 |
| 2024/04/30 | HY-103236 | 1905453-18-0 NSC232003 | 1905453-18-0 | 10mM * 1mLin Water | 1674元 |