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3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE

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3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE Suppliers list
Company Name: Creative Enzymes
Tel: 1-516-855-7709
Email: info@creative-enzymes.com
Products Intro: Product Name:histone deacetylase
Remarks:A class of enzymes that remove acetyl groups from N6-acetyl-lysine residues on a histone. The reaction of this enzyme is opposite to that of EC 2.3.1.48, histone acetyltransferase. Histone deacetylase
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:MC-1353；APHA-8;Aroyl pyrrole hydroxy amide #8;MC 1353;APHA Compound 8;MC1353
CAS:676599-90-9
Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:APHA Compound 8
CAS:676599-90-9
Purity:98% Package:$79.9/1mg;Bulk package Remarks:98%
Company Name: VDM Biochemicals   
Tel: 0330-2528181
Email: sales@vdmbio.com
Products Intro: Product Name:APHA CoMpound 8
CAS:676599-90-9
Purity:>=98%
Company Name: Syntechem Co.,Ltd  
Tel:
Email: info@syntechem.com
Products Intro: Product Name:(E)-N-hydroxy-3-(1-Methyl-4-(2-phenylacetyl)-1H-pyrrol-2-yl)acrylaMide
CAS:676599-90-9
Purity:97% Package:1g;5g;25g;100g;250g;1kg;5kg;10kg;25kg Remarks:we offer low price custom synthesis and contract manufacturing
3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE Basic information
Product Name:3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE
Synonyms:3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE;APHA COMPOUND 8;(E)-N-hydroxy-3-(1-Methyl-4-(2-phenylacetyl)-1H-pyrrol-2-yl)acrylaMide;2-Propenamide, N-hydroxy-3-[1-methyl-4-(2-phenylacetyl)-1H-pyrrol-2-yl]-;APHA-8;Aroyl pyrrole hydroxy amide #8;MC 1353;MC1353
CAS:676599-90-9
MF:C16H16N2O3
MW:284.31
EINECS:
Product Categories:Histone Deacetylase (HDAC) inhibitor.
Mol File:676599-90-9.mol
3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE Structure
3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE Chemical Properties
storage temp. 2-8°C
solubility DMSO: 10 mg/mL, soluble
form solid
Safety Information
Hazard Codes Xn
Risk Statements 22-41-43
Safety Statements 26-36/37/39
WGK Germany 2
MSDS Information
ProviderLanguage
SigmaAldrich English
3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE Usage And Synthesis
DescriptionAPHA compound 8 is an inhibitor of class I histone deacetylases (HDACs; IC50s = 3.7, 7.4, 0.42, and 2.8 μM for HDAC1, -2, -3, and -8, respectively) as well as class II HDACs (IC50s = 3.1, 0.1, 3.1, and 4.2 μM for HDAC4, -6, -7, and -10, respectively). It is selective for class I and II HDACs over class III HDACs (IC50s = >30 μM for SIRT1, SIRT2, and SIRT3) and the histone acetyltransferase PCAF (IC50 = >30 μM). At 48 hours post-infection, APHA compound 8 increases replication of oncolytic herpes simplex virus (oHSV) in MDA-MB-231 and 4T1 breast cancer cells when used prior to viral infection at concentrations of 10 and 50 μM.
3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE Preparation Products And Raw materials
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