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| (E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide(WXC09160) Basic information |
Product Name: | (E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide(WXC09160) | Synonyms: | B355252 2-[(1,4-Dimethylpiperazin-2-ylidene)
amino]-5-nitro-N-phenylbenzamide;2-[(1,4-Dimethylpiperazin-2-ylidene)amino]-5-nitro-N-phenylbenzamide;Benzamide, 2-[(E)-(1,4-dimethyl-2-piperazinylidene)amino]-5-nitro-N-phenyl-;ML-336;(E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide;(E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide(WXC09160);ML 336,VEEV V3526 CPE,inhibit,VEEV TC-83 CPE,ML-336,ML336,Virus Protease,VEEV,VEEV Wild Type CPE,venezuelan equine encephalitis virus,Inhibitor | CAS: | 1613465-33-0 | MF: | C19H21N5O3 | MW: | 367.4 | EINECS: | | Product Categories: | | Mol File: | 1613465-33-0.mol | ![(E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide(WXC09160) Structure](CAS/20180713/GIF/1613465-33-0.gif) |
| (E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide(WXC09160) Chemical Properties |
density | 1.29±0.1 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | ≤0.2mg/ml in ethanol;10mg/ml in DMSO;20mg/ml in dimethyl formamide | form | crystalline solid | pka | 12.30±0.70(Predicted) | color | Off-white to yellow |
| (E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide(WXC09160) Usage And Synthesis |
Biological Activity | ml-336 is an inhibitor for veev-induced cytopathic effect.alphaviruses like venezuelan equine encephalitis virus (veev) are positive-sense, enveloped, single stranded rna viruses that are widely geographically distributed. veevs are found to be arthropod-borne viruses that are known to cause arthritis, encephalitis, rash, as well as death in humans. | in vitro | ml336 was identified as a first-in-class probe that inhibited a veev-induced cytopathic effect in three strains of the virus, which were v3526, tc-83, and trinidad donkey, in the low nanomolar range without having cytotoxicity (> 50 μm, selectivity index > 1500). in addition, ml336 could reduce viral titer (more than 7.2 log) dramatically below a 1 μm drug concentration. furthermore, ml336 showed a favorable in vitro pk profile that included moderate blood-brain barrier permeability. more importantly, ml336 seemed to be able to target the veev [1]. | IC 50 | 32, 20, and 41 nm for tc-83, v3526, and trinidad donkey strains, respectively. | references | [1] chung d et al. ml336: development of quinazolinone-based inhibitors against venezuelan equine encephalitis virus (veev). probe reports from the nih molecular libraries program. bethesda (md): national center for biotechnology information (us); 2010-2012 dec 17. |
| (E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide(WXC09160) Preparation Products And Raw materials |
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