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| | 3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one Basic information |
| Product Name: | 3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one | | Synonyms: | 3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one;NCGC00029283;NCGC00029283,NCGC-00029283;2(1H)-Quinolinone, 3-[5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl]-6-methoxy-;3-(5-(4-Fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2-ol | | CAS: | 714240-31-0 | | MF: | C18H12FN3O3 | | MW: | 337.3 | | EINECS: | | | Product Categories: | | | Mol File: | 714240-31-0.mol |  |
| | 3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one Chemical Properties |
| density | 1.365±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | pka | 9.37±0.70(Predicted) | | form | Solid | | color | White to yellow |
| | 3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one Usage And Synthesis |
| Biological Activity | NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC50s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively[1].
NCGC00029283 (0-100 μM; 24-72 h) effectively blocks cell proliferation in U2-OS cells[1]. | | References | [1]. Joshua A Sommers, et al. A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN). PLoS One. 2019 Jan 9;14(1):e0210525. |
| | 3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one Preparation Products And Raw materials |
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