| Company Name: |
Riedel-de Haen AG
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| Tel: |
800 558-9160 |
| Email: |
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| Products Intro: |
Purity:(Single band on SDS-PAGE), liquid
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| Company Name: |
SIGMA-RBI
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| Tel: |
800 736 3690 (Orders) |
| Email: |
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| Products Intro: |
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| | TOPO II, P170 HUMAN Basic information |
| Product Name: | TOPO II, P170 HUMAN | | Synonyms: | TOPOISOMERASE II A HUMAN;TOPO II, P170 HUMAN;TOPO(R) II, p170;Topoisomerase II α human;TOPO? II, p170 | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![TOPO II, P170 HUMAN Structure]() |
| | TOPO II, P170 HUMAN Chemical Properties |
| storage temp. | −70°C | | form | liquid |
| | TOPO II, P170 HUMAN Usage And Synthesis |
| Uses | Human topoisomerase II α has been used in DNA cleavage assay. | | General Description | Topoisomerase II α is encoded by TOP2A gene, which is located on 17q21.2 in the human chromosome. It is essential for controlling the topological state of DNA by reversibly breaking the DNA strands during replication, recombination and transcription. TOP2A expression increases at late S phase and during G2/M of the cell cycle and decreases after mitosis. Polymorphism with TOP2A causes chromosome instability and tumorigenesis. TOP2A causes tumor proliferation and invasiveness in various cancer types like breast cancer, ovarian cancer and prostate cancer. | | Biochem/physiol Actions | Used to study DNA structure and topology. |
| | TOPO II, P170 HUMAN Preparation Products And Raw materials |
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